Apoptosis Inducing
Apoptosis inducers exhibit pro-apoptotic effects through a variety of mechanisms, including DNA cross-linking, inhibition of antiapoptotic proteins and activation of caspases. These inducers may target a specific cellular process in order to induce antitumor or antineoplastic effects.
Products for Apoptosis Inducing
- Cat.No. Product Name Information/Activity
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BCC2385
Actinomycin D
Actinomycin D (Dactinomycin) inhibits DNA repair with an IC50 of 0.42 μM. Actinomycin D is an autophagy activator.
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BCC3599
Apicidin
Apicidin (OSI 2040) is a fungal metabolite, acts as a histone deacetylase (HDAC) inhibitor, with antiparasitic activity and a broad spectrum antiproliferative activity.
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BCC2099
Apoptosis Activator 2
MDK83190 is a potent apoptosis activator, induces Apaf-1 oligomerization, increases procaspase-9 processing and subsequent caspase-3 activation in a cyto c-dependent Manner.
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BCC1375
Gossypolone
Downregulates Bcl-2 and Mcl-1; pro-apoptotic
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BCC1397
BAM7
BAM7 is a direct and selective activator of proapoptotic BAX with an IC50 of 3.3 μM.
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BCC1153
Bendamustine HCl
Bendamustine hydrochloride is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties.
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BCN5524
Betulinic acid
Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC50 of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties. Betulinic acid acts as a new activator of NF-kB.
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BCC2386
C 75
trans-C75 ((±)-C75) is an enantiomer of C75. C75 is a synthetic fatty-acid synthase (FASN) inhibitor.
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BCC1170
Carboplatin
Carboplatin (NSC 241240) is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death. Carboplatin (NSC 241240) is a derivative of CDDP and a potent anti-cancer agent.
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BCC8017
CFM 4
331458-02-7
