Protein Kinase C

Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Conventional PKCs (cPKC α -, β I- , β II- and γ -) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol.

Products for Protein Kinase C

Cat.No. Product Name Information/Activity
BCC7868 Bisindolylmaleimide II 137592-45-1
BCC6687 C-1 HA-100 is an inhibitor of cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase with IC50s of 4, 8, 12 and 240 μM, respectively.
BCC7131 Calphostin C 121263-19-2
BCC7363 CGP 53353 145915-60-2
BCC6778 Dihydrosphingosine 3102-56-5
BCC1100 Enzastaurin (LY317615) Enzastaurin is a potent and selective PKCβ inhibitor with an IC50 of 6 nM, showing 6- to 20-fold selectivity over PKCα, PKCγ and PKCε.
BCC3704 GF 109203X Bisindolylmaleimide I (GF109203X) is a highly selective, cell-permeable, and reversible protein kinase C (PKC) inhibitor with a Ki of 14 nM.
BCC3705 Go 6983 Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ, PKCδ and PKCζ with IC50 of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively.
BCC3706 K-252c K-252c, a staurosporine analog isolated from Nocardiopsis sp., is a cell-permeable PKC inhibitor, with an IC50 of 2.45 µM. K-252c induces apoptosis in human chronic myelogenous leukemia cancer cells. K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase.
BCC5835 [Ala107]-MBP (104-118) 99026-77-4