Asthma Research

Asthma is a common chronic inflammatory disease of the respiratory system that affects approximately 22 million people in US. It has been classified as a complex genetic condition that is determined by the interaction of numerous genes along with environmental factors.

Asthma Research Products Targets

Products for Asthma Research - Page 11

Cat.No. Product Name Information/Activity
BCC4517 Cetirizine DiHCl Cetirizine dihydrochloride, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine dihydrochloride marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].
BCC4528 Clemastine Fumarate Clemastine (fumarate) (HS-592 (fumarate)) is a selective histamine H1 receptor antagonist with IC50 of 3 nM.
BCC1486 Clemizole hydrochloride Clemizole hydrochloride is an H1 histamine receptor antagonist, is found to substantially inhibit HCV replication. The IC50 of Clemizole for RNA binding by NS4B is 24±1 nM, whereas its EC50 for viral replication is 8 µM.
BCC4540 Desloratadine Desloratadine(Sch34117) is a potent antagonist for human histamine H1 receptor used to treat allergies.
BCC7061 (S)-(+)-Dimethindene maleate 136152-65-3
BCC4542 Fexofenadine HCl Fexofenadine hydrochloride (MDL-16455 hydrochloride), a H1R antagonist, is an anti-allergic agent used in seasonal allergic rhinitis and chronic idiopathic urticarial (person aged ≥16 years).
BCC1262 Loratadine Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity.
BCC6740 Mepyramine maleate Mepyramine maleate, a first generation antihistamine, is an antagonist of histamine H1 receptor, with Kds of 0.8 nM, 5200 nM and >3000 nM for H1, H2, and H3 receptor, respectively, and a pKd of 9.4 for H1 receptor.
BCC4923 Mirtazapine Mirtazapine is a 5-HT receptor inhibitor. Mirtazapine is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent by blocking 5-HT2 and 5-HT3 receptors.
BCC4545 Olopatadine HCl Olopatadine hydrochloride (ALO4943A) is a histamine blocker used to treat allergic conjunctivitis.