Immune Cell Signaling

Immune cells are functionally regulated by key signaling pathways, which mediate immune function by enabling a response to various stimuli. This response must be carefully moderated in order to avoid hyperresponsiveness or inadequacy in the presence of foreign antigens.

Immune Cell Signaling Products Targets

Products for Immune Cell Signaling - Page 5

Cat.No. Product Name Information/Activity
BCN2315 Pristimerin Pristimerin is a potent and reversible monoacylglycerol lipase (MGL) inhibitor with an IC50 of 93 nM.
BCC7949 PS 1145 dihydrochloride 1049743-58-9
BCC1124 PSI 158442-41-2
BCC6766 Pyrrolidinedithiocarbamate ammonium Pyrrolidinedithiocarbamate ammonium (Ammonium pyrrolidinedithiocarbamate) is a selective NF-κB inhibitor.
BCC7175 Ro 106-9920 62645-28-7
BCC4554 SC-514 SC-514 is a selective IKK-2 inhibitor (IC50=11.2 μM), which does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.
BCC2545 Sulfasalazine Sulfasalazine is a drug for the treatment of rheumatoid arthritis and ulcerative colitis. Sulfasalazine is reported to suppress NF-κB activity.
BCN5763 Tanshinone IIA Tanshinone IIA (Tan IIA) is one of the main fat-soluble compositions in the root of red-rooted salvia. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2.
BCC2473 TPCA-1 TPCA-1 is a potent and selective inhibitor of IKK-2 with IC50 of 17.9 nM. TPCA-1 is an effective inhibitor of STAT3 phosphorylation, DNA binding, and transactivation.
BCC7495 Withaferin A Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities.