JAK

JAKs (or Janus kinases) are a family of tyrosine kinases that are associated with cytokine receptors. Upon receptor activation JAKs phosphorylate the transcription factors known as STATs and initiate the JAK-STAT signaling pathway. Four JAK family members have been identified.

Products for JAK

Cat.No. Product Name Information/Activity
BCC2193 AG-490 AG-490 is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.
BCC2191 AZD1480 AZD-1480 is an ATP-competitive inhibitor of JAK1 and JAK2 with IC50s of 1.3 nM and <0.4 nM, respectively.
BCC2438 Cercosporamide Cercosporamide is a highly potent, ATP-competitive Pkc1 kinase inhibitor, with an IC50 of <50 nM and a Ki of <7 nM. Cercosporamide is a unique Mnk inhibitor.
BCC2439 Cucurbitacin I Cucurbitacin I is a natural selective inhibitor of JAK2/STAT3, with potent anti-cancer activity.
BCC2437 1,2,3,4,5,6-Hexabromocyclohexane Inhibits JAK2 autophosphorylation
BCC2441 NSC 33994 JAK2 inhibitor
BCC2442 SD 1008 JAK2/STAT3 signaling pathway inhibitor
BCC2443 TCS 21311 TCS 21311 (NIBR3049) is a potent, highly selective JAK3 inhibitor with an IC50 of 8 nM, it displays >100-fold selectivity over JAK1, JAK2 and TYK2. TCS 21311 (NIBR3049) inhibits PKCα, PKCθ, and GSK3β with IC50s of 13, 68, and 3 nM, respectively.
BCC2202 WHI-P154 WHI-P154 is a potent EGFR inhibitor, and also modestly blocks JAK3, with IC50s of 4 nM and 1.8 μM, respectively.
BCC2444 ZM 449829 Potent, selective JAK3 inhibitor