Immune Cell Signaling

Immune cells are functionally regulated by key signaling pathways, which mediate immune function by enabling a response to various stimuli. This response must be carefully moderated in order to avoid hyperresponsiveness or inadequacy in the presence of foreign antigens.

Immune Cell Signaling Products Targets

Products for Immune Cell Signaling - Page 2

Cat.No. Product Name Information/Activity
BCC7057 1400W dihydrochloride 1400W dihydrochloride is a potent and selective inhibitor of human inducible NO synthase with Ki values of 7 nM.
BCC2193 AG-490 AG-490 is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.
BCC2191 AZD1480 AZD-1480 is an ATP-competitive inhibitor of JAK1 and JAK2 with IC50s of 1.3 nM and <0.4 nM, respectively.
BCC2438 Cercosporamide Cercosporamide is a highly potent, ATP-competitive Pkc1 kinase inhibitor, with an IC50 of <50 nM and a Ki of <7 nM. Cercosporamide is a unique Mnk inhibitor.
BCC2439 Cucurbitacin I Cucurbitacin I is a natural selective inhibitor of JAK2/STAT3, with potent anti-cancer activity.
BCC2437 1,2,3,4,5,6-Hexabromocyclohexane Inhibits JAK2 autophosphorylation
BCC2441 NSC 33994 JAK2 inhibitor
BCC2442 SD 1008 JAK2/STAT3 signaling pathway inhibitor
BCC2443 TCS 21311 TCS 21311 (NIBR3049) is a potent, highly selective JAK3 inhibitor with an IC50 of 8 nM, it displays >100-fold selectivity over JAK1, JAK2 and TYK2. TCS 21311 (NIBR3049) inhibits PKCα, PKCθ, and GSK3β with IC50s of 13, 68, and 3 nM, respectively.
BCC2202 WHI-P154 WHI-P154 is a potent EGFR inhibitor, and also modestly blocks JAK3, with IC50s of 4 nM and 1.8 μM, respectively.