Estrogen and Related Receptor
Estrogen controls many cellular processes including growth, differentiation and function of the reproductive system. Estrogen is also responsible for the growth and maintenance of the skeleton and the normal function of the cardiovascular and nervous systems.
Products for Estrogen and Related Receptor - Page 2
- Cat.No. Product Name Information/Activity
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BCN2750
27-Hydroxycholesterol
27-Hydroxycholesterol is a selective estrogen receptor modulator and an agonist of the liver X receptor.
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BCN5946
Liquiritigenin
Liquiritigenin, a flavanone isolated from Glycyrrhiza uralensis, is a highly selective estrogen receptor β (ERβ) agonist with an EC50 of 36.5 nM for activation of the ERE tk-Luc.
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BCC7062
PPT
Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%).
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BCC7669
WAY 200070
WAY-200070 is a selective estrogen receptor β (ERRβ) agonist with an IC50 of 2.3 nM.
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BCC1081
Fulvestrant
Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC50 of 9.4 nM. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC50 of 0.29 nM. Fulvestrant also induces autophagy and apoptosis and has antitumor efficacy.
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BCC7225
MPP dihydrochloride
MPP dihydrochloride is a highly selective estrogen receptor alpha (ERα) antagonist. MPP dihydrochloride reduces the ratio of p-ERα/ERα.
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BCC7447
PHTPP
PHTPP is a selective ERβ antagonist.
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BCC5121
XCT790
XCT-790 is a potent and selective inverse agonist for ERRα with an IC50 value of 0.37 μM. XCT-790 induces cell death in chemotherapeutic resistant cancer cells. XCT-790 (Compound 12) is inactive against ERRγ and the estrogen receptors ERα and ERβ.
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BCC7272
ZK 164015
177583-70-9
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BCC1412
Bazedoxifene acetate
Bazedoxifene acetate (TSE-424 acetate) is a third generation selective estrogen receptor modulator (SERM) with IC50s of 26 and 99 nM for ERα and ERβ, respectively.
