Multiple Sclerosis

Multiple sclerosis (MS) is a chronic autoimmune, inflammatory disease of the central nervous system (CNS), which causes damage to myelin and axons, resulting in neurological symptoms such as partial loss of sight, paresthesias and ataxia.

Multiple Sclerosis Products Targets

Products for Multiple Sclerosis - Page 3

Cat.No. Product Name Information/Activity
BCC1122 TRAM-34 TRAM-34 is a highly selective blocker of intermediate-conductance calcium-activated K+ channel (IKCa1) (Kd=20 nM).
BCC8038 TRAM 39 Potent K<sub>Ca</sub>3.1 blocker
BCC7016 UCL 1684 199934-16-2
BCC7446 UCL 2077 UCL 2077 is a selective slow-afterhyperpolarization (sAHP) channel blocker (IC50 = 500 nM in hippocampal neurons in culture), having minimal effects on Ca2+ channels, action potentials, input resistance and the medium after hyperpolarization. UCL 2077 is also a subtype-selective blocker of the epilepsy associated KCNQ channels.
BCC7886 BTZO 1 BTZO-1 binds to Macrophage migration inhibitory factor (MIF) with a Kd value of 68.6 nM, and its binding requires the N-terminal Pro1. BTZO-1 can activate antioxidant response element (ARE)-mediated gene expression and suppress oxidative stress-induced cardiomyocyte apoptosis in vitro.
BCC6816 Chicago Sky Blue 6B 2610-05-1
BCC6161 (±)-CPSI 1306 (±)-CPSI-1306 is an orally available antagonist of macrophage migration inhibitory factor (MIF).
BCC5914 ER 27319 maleate 1204480-26-1
BCC2096 Gabexate mesylate Gabexate mesylate is a Factor X inhibitor; serine protease inhibitor .
BCC5203 VGX-1027 VGX-1027(GIT27) is an isoxazole compound that exhibits various immunomodulatory properties; reduce the secretion of IL-1beta, TNF-alpha and IL-10 from purified murine macrophages.