Parkinson's Disease Research

Parkinson's disease (PD) is a degenerative disease of the central nervous system that often impairs motor skills, speech, and other functions. Symptoms of the disease include resting tremor, bradykinesia and rigidity. The primary symptoms are the result of decreased stimulation of the motor cortex by the basal ganglia, normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the brain. Symptoms of the disease appear once 50-80% of dopamine neurons have died. Parkinson's disease is both chronic and progressive.

Parkinson's Disease Research Products Targets

Products for Parkinson's Disease Research - Page 70

  1. Cat.No. Product Name Information/Activity
  2. BCC4595 VU 0357121 VU0357121 is a novel positive and highly selective allosteric modulator (PAM) of mGlu5R with EC50 of 33 nM. VU 0357121 chemical structure
  3. BCC6141 VU 0360172 hydrochloride 1309976-62-2 VU 0360172 hydrochloride chemical structure
  4. BCC6159 VU 0360223 1274859-33-4 VU 0360223 chemical structure
  5. BCC7649 VU 1545 890764-63-3 VU 1545 chemical structure
  6. BCC7936 VU 29 890764-36-0 VU 29 chemical structure
  7. BCC6969 (2R,4R)-APDC (2R,4R)-APDC is a selective group II metabotropic glutamate receptors (mGluRs) agonist. (2R,4R)-APDC has anticonvulsant and neuroprotective effects. (2R,4R)-APDC chemical structure
  8. BCC6609 L-CCG-l 117857-93-9 L-CCG-l chemical structure
  9. BCC5691 DCG IV DCG-IV is a potent agonist of group II mGluRs with EC50s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC50: mGlu1/5R=389/630 μM) and III receptors (IC50: mGlu4/6/7/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects. DCG IV chemical structure
  10. BCC7614 LY 354740 Eglumegad (LY354740) is a highly potent and selective group II (mGlu2/3) receptor agonist with IC50s of 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively. LY 354740 chemical structure
  11. BCC7368 LY 379268 Highly selective group II mGlu agonist LY 379268 chemical structure

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