Parkinson's Disease Research

Parkinson's disease (PD) is a degenerative disease of the central nervous system that often impairs motor skills, speech, and other functions. Symptoms of the disease include resting tremor, bradykinesia and rigidity. The primary symptoms are the result of decreased stimulation of the motor cortex by the basal ganglia, normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the brain. Symptoms of the disease appear once 50-80% of dopamine neurons have died. Parkinson's disease is both chronic and progressive.

Parkinson's Disease Research Products Targets

Products for Parkinson's Disease Research - Page 68

  1. Cat.No. Product Name Information/Activity
  2. BCC6611 (S)-MCPG (S)-MCPG is the active isomer of (RS)-MCPG (Cat. (S)-MCPG chemical structure
  3. BCC1777 MPEP Hydrochloride MPEP hydrochloride is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype with IC50 of 36 nM. MPEP Hydrochloride chemical structure
  4. BCC1780 MTEP hydrochloride MTEP hydrochloride is a potent, selective and non-competitive mGlu5 antagonist with an IC50 of 5 nM and a Ki of 16 nM. MTEP hydrochloride produces antiparkinsonian-like effects. MTEP hydrochloride chemical structure
  5. BCC6119 NPS 2390 226878-01-9 NPS 2390 chemical structure
  6. BCC6895 PHCCC PHCCC is a Group I metabotropic glutamate receptor antagonist with EC 50 of 6 uM and a positive allosteric modulator of mGluR4. Also as a potent to antagonism for mGluR2 and mGluR8. PHCCC chemical structure
  7. BCC6971 SIB 1757 31993-01-8 SIB 1757 chemical structure
  8. BCC7682 YM 202074 299900-84-8 YM 202074 chemical structure
  9. BCC5956 YM 230888 446257-23-4 YM 230888 chemical structure
  10. BCC7366 YM 298198 hydrochloride 1216398-09-2 YM 298198 hydrochloride chemical structure
  11. BCC7365 Desmethyl-YM 298198 1177767-57-5 Desmethyl-YM 298198 chemical structure

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