Parkinson's Disease Research

Parkinson's disease (PD) is a degenerative disease of the central nervous system that often impairs motor skills, speech, and other functions. Symptoms of the disease include resting tremor, bradykinesia and rigidity. The primary symptoms are the result of decreased stimulation of the motor cortex by the basal ganglia, normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the brain. Symptoms of the disease appear once 50-80% of dopamine neurons have died. Parkinson's disease is both chronic and progressive.

Parkinson's Disease Research Products Targets

Products for Parkinson's Disease Research - Page 67

  1. Cat.No. Product Name Information/Activity
  2. BCC6888 E4CPG E4CPG is a novel group I/group II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG . E4CPG chemical structure
  3. BCC7345 Fenobam Fenobam is a selective, orally active, and non-competitive mGluR5 antagonist acting at an allosteric modulatory site (Kd values are 54 and 31 nM for rat and human recombinant mGlu5 receptors, respectively). Fenobam displays inverse agonist activity which blocks the mGlu5 receptor basal activity with an IC50 of 84 nM. Fenobam exerts anxiolytic activity. Fenobam chemical structure
  4. BCC7166 HexylHIBO 334887-43-3 HexylHIBO chemical structure
  5. BCC7167 (S)-HexylHIBO 334887-48-8 (S)-HexylHIBO chemical structure
  6. BCC7332 JNJ 16259685 JNJ16259685 is a selective antagonist of mGlu1 receptor, and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with IC50 of 19 nM. JNJ 16259685 chemical structure
  7. BCC6983 LY 367385 LY367385 is a highly potent and selective mGluR1a antagonist. LY367385 has an IC50 of 8.8 μM for inhibits of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with > 100 μM for mGlu5a. LY367385 has neuroprotective, anticonvulsant and antiepileptic effects. LY 367385 chemical structure
  8. BCC7347 LY 456236 hydrochloride 338736-46-2 LY 456236 hydrochloride chemical structure
  9. BCC7281 3-MATIDA 518357-51-2 3-MATIDA chemical structure
  10. BCC7756 (RS)-MCPG disodium salt 1303994-09-3 (RS)-MCPG disodium salt chemical structure
  11. BCC6610 (RS)-MCPG (RS)-MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS)-MCPG blocks theta-burst stimulation (TBS)-induced shifts in both juvenile and neonatal rat hippocampal neurons. (RS)-MCPG chemical structure

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