(RS)-MCPG disodium saltNon-selective mGlu antagonist CAS# 1303994-09-3 |
2D Structure
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Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
Cas No. | 1303994-09-3 | SDF | Download SDF |
PubChem ID | 122715595 | Appearance | Powder |
Formula | C10H9NNa2O4 | M.Wt | 253.16 |
Type of Compound | N/A | Storage | Desiccate at -20°C |
Solubility | Soluble to 100 mM in water | ||
Chemical Name | disodium;2-(4-carboxyanilino)propanoate | ||
SMILES | CC(C(=O)[O-])NC1=CC=C(C=C1)C(=O)O.CC(C(=O)[O-])NC1=CC=C(C=C1)C(=O)O.[Na+].[Na+] | ||
Standard InChIKey | CNBGOFNYJRMHJC-UHFFFAOYSA-L | ||
Standard InChI | InChI=1S/2C10H11NO4.2Na/c2*1-6(9(12)13)11-8-4-2-7(3-5-8)10(14)15;;/h2*2-6,11H,1H3,(H,12,13)(H,14,15);;/q;;2*+1/p-2 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | Sodium salt of (RS)-MCPG, a non-selective group I/group II metabotropic glutamate receptor antagonist. |
(RS)-MCPG disodium salt Dilution Calculator
(RS)-MCPG disodium salt Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 3.9501 mL | 19.7504 mL | 39.5007 mL | 79.0014 mL | 98.7518 mL |
5 mM | 0.79 mL | 3.9501 mL | 7.9001 mL | 15.8003 mL | 19.7504 mL |
10 mM | 0.395 mL | 1.975 mL | 3.9501 mL | 7.9001 mL | 9.8752 mL |
50 mM | 0.079 mL | 0.395 mL | 0.79 mL | 1.58 mL | 1.975 mL |
100 mM | 0.0395 mL | 0.1975 mL | 0.395 mL | 0.79 mL | 0.9875 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
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Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1.[Pubmed:7751958]
J Neurosci. 1995 May;15(5 Pt 2):3970-81.
The main excitatory neurotransmitter in the brain, glutamate (Glu), activates not only receptor-channels, but also receptors coupled to G-protein called metabotropic Glu receptors (mGluRs). Eight genes coding for mGluRs have been characterized to date giving rise to even more proteins due to alternative splicing phenomena. Here we characterized a splice variant of mGluR5, called mGluR5b which contains a 32 amino acid fragment inserted in the cytoplasmic tail, 50 residues after the 7th transmembrane domain. mGluR5b mRNAs are present in different regions of the adult rat brain and are expressed at a higher level than mGluR5a mRNA. Functional analysis of mGluR5a and mGluR5b revealed that they share all the properties of mGluR1a, but not those of mGluR1b or 1c. Like mGluR1a, both mGluR5a and mGluR5b activate a rapid and transient current in Xenopus oocytes. When expressed in LLC-PK1 cells, they show the same subcellular distribution as mGluR1a, and stimulate both inositol phosphate (IP) and cAMP production. Moreover, cells expressing mGluR5a or mGluR5b, like those expressing mGluR1a have a higher basal PLC activity that is not inhibited by glutamate-pyruvate transaminase (GPT), suggesting that these receptors have an intrinsic activity. Interestingly, the pharmacological profiles of mGluR5a and b are identical, but different from that of mGluR1a. Most agonists, except glutamate, are more potent on mGluR5a/b than on mGluR1a. Interestingly, the mGluR1a antagonists MCPG and 4CPG have no effect on mGluR5a/b; 4C3HPG which is a full antagonist at mGluR1a is a partial agonist at mGluR5a/b. These results indicate that the long C-terminal intracellular domain present only in mGluR1a and mGluR5a/b, although not well conserved, is likely to be involved in the specific functional properties of these receptors. Although the ligand recognition sites of mGluR5a/b and mGluR1a are highly conserved, these receptors have different pharmacology.
Phenylglycine derivatives as antagonists of metabotropic glutamate receptors.[Pubmed:7992387]
Trends Pharmacol Sci. 1994 Sep;15(9):333-42.
Metabotropic glutamate receptors represent a family of G protein-coupled receptors that can be activated by L-glutamate, the principal excitatory neurotransmitter in the brain. Until recently, progress in identifying the physiological and pathological roles of metabotropic glutamate receptors has been hampered by the lack of selective antagonists. In this article, Jeff Watkins and Graham Collingridge describe the pharmacology of, and initial physiological studies using, certain phenylglycine derivatives and related substances--the first definitive antagonists of metabotropic glutamate receptors.