AC 45594

inverse agonist of steroidogenic factor 1 (SF-1) CAS# 13037-86-0

AC 45594

2D Structure

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3D structure

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AC 45594

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Chemical Properties of AC 45594

Cas No. 13037-86-0 SDF Download SDF
PubChem ID 25641 Appearance Powder
Formula C13H20O2 M.Wt 208.3
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in DMSO > 10 mM
Chemical Name 4-heptoxyphenol
SMILES CCCCCCCOC1=CC=C(C=C1)O
Standard InChIKey HZBABTUFXQLADL-UHFFFAOYSA-N
Standard InChI InChI=1S/C13H20O2/c1-2-3-4-5-6-11-15-13-9-7-12(14)8-10-13/h7-10,14H,2-6,11H2,1H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of AC 45594

DescriptionSelective inverse agonist at the orphan nuclear receptor steroidogenic factor-1 (SF-1) (IC50= 50 - 100 nM). Displays no activity at estrogen, LRH-1, ROR, ERR or Nurr receptors. Inhibits SFRE-mediated transcription.

AC 45594 Dilution Calculator

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AC 45594 Molarity Calculator

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Preparing Stock Solutions of AC 45594

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.8008 mL 24.0038 mL 48.0077 mL 96.0154 mL 120.0192 mL
5 mM 0.9602 mL 4.8008 mL 9.6015 mL 19.2031 mL 24.0038 mL
10 mM 0.4801 mL 2.4004 mL 4.8008 mL 9.6015 mL 12.0019 mL
50 mM 0.096 mL 0.4801 mL 0.9602 mL 1.9203 mL 2.4004 mL
100 mM 0.048 mL 0.24 mL 0.4801 mL 0.9602 mL 1.2002 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on AC 45594

AC 45594 is a full inverse agonist of steroidogenic factor 1 (SF-1) with an IC50 value of 50~100 nM [1].

SF-1 is a constitutively nuclear hormone receptor. It is essential to the development of gonadal and adrenal glands. It acts as a shaping factor in sexual differentiation and determination. Its effects are exerted primarily via controlling steroid hormone synthesis [1].

Human adrenocortical H295R/TR SF-1 cells were overexpressing SF-1 in a Dox-inducible fashion. After a 4-day treatment with AC 45594, the proliferation of H295R/TR SF-1 cells cultured in basal conditions was inhibited in a dose-dependent manner. AC 45594 showed maximal effect at 10 µM. SF-1 overexpression induced cell proliferation. In the presence of Dox, incubation with AC 45594 at 1 µM markedly reduced the effect of SF-1 overexpression. Moreover, treatment with AC 45594 increased the percentage of sub-G1 (apoptotic) cells [2]. In human adrenocortical H295 cells, cAMP is able to induce the expression of StAR. This induction is dependent on the presence of SF-1. Incubation with AC 45594 dose-dependently reduced amounts of the StAR mRNA to basal levels. At the protein level, 24 h after the cAMP treatment, StAR was increased by 30-fold. But treatment with AC 45594 completely and dose-dependently reversed the cAMP-dependent activation of StAR [1].

No result regarding the effect of AC 45594 in animal bodies had been found.

References:
[1].  Del Tredici AL, Andersen CB, Currier EA, et al. Identification of the first synthetic steroidogenic factor 1 inverse agonists: pharmacological modulation of steroidogenic enzymes. Molecular pharmacology, 2008, 73(3): 900-908.
[2].  Doghman M, Cazareth J, Douguet D, et al. Inhibition of adrenocortical carcinoma cell proliferation by steroidogenic factor-1 inverse agonists. The Journal of Clinical Endocrinology & Metabolism, 2009, 94(6): 2178-2183.

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