Pain and Inflammation Research

Although separate conditions, pain and inflammation are nearly always associated with each other. Pain is defined by the International Association for the Study of Pain (IASP) as 'an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage'. Inflammation is the tissue's immunologic response to injury, characterized by mobilization of white blood cells and antibodies, swelling, and fluid accumulation.

Pain and Inflammation Research Products Areas

Products for Pain and Inflammation Research - Page 56

  1. Cat.No. Product Name Information/Activity
  2. BCC7354 A-71623 Potent and selective CCK<sub>1</sub> agonist; suppresses feeding A-71623 chemical structure
  3. BCC7319 Devazepide Devazepide (L-364,718) is a potent, competitive, selective and orally active nonpeptide antagonist of cholecystokinin (CCK) receptor, with IC50s of 81 pM, 45 pM and 245 nM for rat pancreatic, bovine gallbladder and guinea pig brain CCK receptors, respectively. Devazepide (L-364,718) is effective for gastrointestinal disorders. Devazepide chemical structure
  4. BCC7277 SR 27897 Lintitript (SR 27897) is a highly potent, selective, orally active, competitive and non-peptide cholecystokinin (CCK1) receptor antagonist with an EC50 of 6 nM and a Ki of 0.2 nM. Lintitript displays > 33-fold selectivity more selective for CCK1 than CCK2 receptors (EC50 value of 200 nM). Lintitript increases plasma concentration of leptin and food intake as well as plasma concentration of insulin. SR 27897 chemical structure
  5. BCC5958 Gastrin I (human) Gastrin-1, human is the endogenous peptide produced in the stomach, and increases gastric acid secretion via cholecystokinin 2 (CCK2) receptor. Gastrin I (human) chemical structure
  6. BCC7430 CI 988 130332-27-3 CI 988 chemical structure
  7. BCC7477 L-365,260 118101-09-0 L-365,260 chemical structure
  8. BCC6891 LY 225910 133040-77-4 LY 225910 chemical structure
  9. BCC5772 LY 288513 147523-65-7 LY 288513 chemical structure
  10. BCC7431 PD 135158 130285-87-9 PD 135158 chemical structure
  11. BCC7052 YM 022 YM022 is a highly potent, selective and orally active gastrin/cholecystokinin (CCK)-B receptor (CCK-BR) antagonist. YM022 shows the Ki values of 68 pM and 63 nM for CCK-B and CCK-A receptor, respectively. YM022 can inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation in vivo. YM 022 chemical structure

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