Products for Histone Demethylases
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BCC5575
ML324
ML324 is a potent JMJD2 demethylase inhibitor with demonstrated antiviral activity.
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BCC4549
OG-L002
OG-L002 is a potent and highly selective LSD1 inhibitor with an IC50 of 0.02 μM. OG-L002 is a potent monoamine oxidases (MAO) inhibitor with IC50s of 1.38 μM and 0.72 μM for MAO-A and MAO-B, respectively. OG-L002 potently inhibits the expression of HSV IE genes.
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BCC2231
GSK J1
GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with IC50 of 60 nM towards KDM6B.
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BCC2230
GSK J4 HCl
Histone KDM inhibitor; cell permeable,GSK-J4 is a potent <b>H3K27me3 demethylase</b> inhibitor, with <b>IC<sub>50</sub></b>s of 8.6 µM and 6.6 µM towards KDM6B and KDM6A respectively.
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BCC5524
CBB1003
CBB1003 is a novel histone demethylase LSD1 inhibitor with IC50 of 10.54 uM.
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BCC4272
CBB1007
CBB1007 is a cell-permeable amidino-guanidinium compound that acts as a potent, reversible and substrate competitive LSD1 selective inhibitor (IC50 = 5.27 μM for hLSD1).
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BCC6264
GSK J5
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BCC6263
GSK J2
GSK-J2 is an isomer of GSK-J1 that does not have any specific activity. GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A.
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BCC6422
GSK2879552
GSK2879552 is an orally available, irreversible inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity.
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BCC5578
SP2509
SP2509 is a potent and selective antagonist of lysine specific demethylase 1 (LSD1) with IC50 of 13 nM.
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BCC5647
GSK-LSD1 2HCl
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BCC5608
TC-E 5002
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BCC7791
Tranylcypromine hydrochloride
Tranylcypromine is a monoamine oxidase inhibitor, which inhibits CYP2A6 with Ki of 0.08 μM and 0.2 μM in cDNA-expressing microsomes and Human Liver Microsomes, respectively.
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BCC6483
2,4-Pyridinedicarboxylic Acid
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BCC6192
IOX 1
IOX1, 5-Carboxy-8-hydroxyquinoline, is a potent broad‐spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases. IOX1 inhibits KDM4C, KDM4E, KDM2A, KDM3A and KDM6B with IC50 values of 0.6 μM, 2.3 μM, 1.8 μM, 0.1 μM and 1.4 μM, respectively. IOX1 also inhibits ALKBH5.
