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Transferase

Transferases are a collection of a large and diverse group of enzymes that specifically catalyze the transfer of one or more functional groups from one molecule (the donor) to another (the acceptor). A few transferases involved in this category include farnesyltransferase (FTase), diacylglycerol acyltransferase (DGAT) and catechol-O-methyltransferase (COMT). Ftase catalyzes the transfer of a farnesyl moiety to the cysteine terminal residue (the sulfhydryl cysteine of the CAAS motif)) of substrate proteins. DGAT catalyzes the final step of the triacylglycerol (TG) biosynthetic pathway, where diacylglycerol is esterified to produce TG. COMT catalyzes the methylation of catechol substrates utilizing S-adenosyl-L-methionine (SAM) as a methyl donor and generating O-methylated catechol and S-adenosyl-L-homocysteine.

Products for Transferase

  1. Cat.No. Product Name Information
  2. BCC2331 LonafarnibFtase inhibitor,potent and selective
  3. BCC2332 FK866 (APO866)NAMPT inhibitor,non-competitive, highly specific
  4. BCC2333 A922500Potent DGAT-1 inhibitor
  5. BCC2334 TolcaponeCOMT inhibitor; also inhibits transthyretin aggregation
  6. BCC2335 PF-04620110DGAT-1 inhibitor,potent and selective
  7. BCC5344 LB42708Selective farnesyltransferase (FTase) inhibitor
  8. BCC5661 OR-486Catechol O-methyltransferase inhibitor
  9. BCC6109 LY 78335Phenylethanolamine-N-methyltransferase inhibitor
  10. BCC6187 GGsTopγ-glutamyl transpeptidase (GGT) inhibitor, novel and irreversible
  11. BCC6344 Cystamine dihydrochlorideTransglutaminase inhibitor; neuroprotective
  12. BCC6395 FTI 277 HClFTase inhibitor
  13. BCC6675 SKF 91488 dihydrochlorideHistamine N-methyltransferase inhibitor
  14. BCC7685 Tris DBAN-myristoyltransferase-1 inhibitor; antiproliferative
  15. BCC7699 TunicamycinCauses ER stress; can be used to induce autophagy

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