DPP-4
Dipeptidyl peptidase-4 (DPP-4), originally identified in 1966 as a dipeptide naphthylamidase hydrolyzing glycyl-prolyl-beta-naphthylamide, is a membrane-associated peptidase that selectively cleaves the N-terminal penultimate proline or alanine amino acids. The most common substrates of DPP-4 include glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2), peptide YY, neuropeptide, chemokine ligand 12/stromal-derived factor-1 (CXCL12/SDF-1) and substance P. DPP-4, as a type II cell surface protein and a soluble form, has been found to be widely distributed in organs (such as the bone marrow, the lung, spleen, liver, pancreas, kidney and intestines) and body fluids (such as serum/plasma, cerebrospinal fluid, synovial fluid and semen). Besides its peptidase activity, DPP-4 has been found to be associated with immune stimulation, extracellular matrix degradation, lipid accumulation and resistance to anticancer agents.
Products for DPP-4
- Cat.No. Product Name Information
- BCC1341 Alogliptin BenzoateDPP-4 inhibitor,selective and potent,antidiabetic drug
- BCC1992 Teneligliptin hydrobromideDipeptidyl peptidase-4 inhibitor
- BCC2014 TrelagliptinDPP-4 inhibitor,long-acting and selective
- BCC2015 Trelagliptin succinateDPP-4 inhibitor
- BCC2109 GlimepirideKir6 (KATP) channel blocker
- BCC2110 Linagliptin (BI-1356)DDP-4 inhibitor,highly potent and competitive
- BCC2111 Sitagliptin phosphate monohydratePotent DPP-4 inhibitor
- BCC2112 Vildagliptin (LAF-237)DPP-4 inhibitor
- BCC2113 Alogliptin (SYR-322)DPP-4 inhibitor,potent and highly selective
- BCC2363 DPPI 1c hydrochlorideDPP-IV Inhibitor
- BCC2364 K 579Dipeptidyl peptidase IV (DPP-IV) inhibitor
- BCC2365 NVP DPP 728 dihydrochlorideDPP-IV inhibitor
- BCC2366 PK 44 phosphateDPP-IV inhibitor
- BCC3934 SaxagliptinSelective DPP4 inhibitor
- BCC5357 Talabostat mesylateorally active, specific inhibitor of DPP4
- BCC6417 MK3102Novel long-acting DPP-4 inhibitor