Products with Anti-inflammatory bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN3669 | Tilianin |
| 1. Tilianin has anti-inflammatory activity. 2. Tilianin has antiatherogenic activity. 3. Tilianin inhibits the tumor necrotic factor-K (TNF-K)-induced expression of VCAM-1 by 74% and reduces TNF-K-induced activation of nuclear factor-UB in cultured human umbilical vein endothelial cells (HUVECs). 4. Tilianin has antihypertensive and vasorelaxant activities, mediates relaxation and antihypertension mainly by an endothelium-dependent manner, probably due to NO release, and also through an endothelium-independent pathway by opening K+ channels. | |
| BCN3673 | 7-Hydroxyflavone |
| 7-Hydroxyflavone is a potent inhibitor of CYP1A1 with a Ki value of 0.015 μM and exhibits 6-fold greater selectivity for CYP1A1 over CYP1A2. It also has excellent antioxidant, anti-inflammatory, and anti-proliferation properties, it may serve as potential protective agents in the treatment of patients with chronic EV71 infection.7-Hydroxyflavone can protect renal cells from NIC-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway; it also can inhibit LPS-induced inflammation via attenuating the production of NO, PGE2 , TNF-α and IL-6. | |
| BCN3688 | Thunalbene |
| 1. Thunalbene shows weak inhibitory activities without cytotoxicity on the production of nitric oxide (NO) which is an important inflammatory mediator. | |
| BCN3715 | Stylopine |
| 1. Stylopine can serve as a model compound for the design and future development of structurally related AKR1C3 inhibitors. 2. Stylopine suppresses the NO and PGE2 production in macrophages by inhibiting the iNOS and COX-2 expressions, may contribute to the anti-inflammatory activity of Chelidonium majus. | |
| BCN3735 | Sappanol |
| 1. Sappanol inhibits lipid peroxidation in a concentration-dependent manner, can significantly attenuated H2O2-induced retinal death, can be potential antioxidant treatment for retinal diseases. | |
