Products with Anti-leishmanial bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN3747 | Dihydrocorynantheine |
| 1. Dihydrocorynantheine exhibits significant vasodilating activity against phenylephrine-induced contraction in rat thoracic aorta rings (IC(50) = 6.73 μg/mL), it also shows weak inhibitory action on KCl-induced contraction. 2. Dihydrocorynantheine shows pronounced activity against Leishmania major promastigotes (IC50 at the micromolar level) but no significant in vitro antiplasmodial activity (against chloroquinesensitive Plasmodium falciparum). | |
| BCN3762 | Coronaridine |
| 1. Coronaridine is an antitumor agent. 2. Coronaridine congeners inhibit hα3β4 AChRs by blocking the ion channel's lumen and probably by additional negative allosteric mechanisms by interacting with a series of non-luminal sites. | |
| BCN4016 | Tubotaiwine |
| 1. Tubotaiwine shows selective activity against L. infantum. 2. Tubotaiwine and apparicine have affinity for adenosine receptors in the micromolar range and also have in-vivo analgesic activity in mice. | |
| BCN4020 | 6,7-Dihydroneridienone A |
| 1. 6,7-Dihydroneridienone A exhibits notable leishmanicidal activity. | |
| BCN4037 | Piplartine |
| 1. Piplartine shows potential anti-malaria and anti- leishmaniasis activities. 2. Piplartine shows inhibitory activities of platelet aggregation induced by ADP and AA in vitro . 3. Piplartine displays in vitro and in vivo anticancer efficacy. 4. Piplartine induces in vivo and in vitro mutagenicity in eukaryotic models. | |
