DihydrocorynantheineCAS# 4684-43-9 |
- Hirsutine
Catalog No.:BCN2758
CAS No.:7729-23-9
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 4684-43-9 | SDF | Download SDF |
PubChem ID | 5316699 | Appearance | Cryst. |
Formula | C22H28N2O3 | M.Wt | 368.5 |
Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | methyl (E)-2-[(3R)-3-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl]-3-methoxyprop-2-enoate | ||
SMILES | CCC1CN2CCC3=C(C2CC1C(=COC)C(=O)OC)NC4=CC=CC=C34 | ||
Standard InChIKey | NMLUOJBSAYAYEM-WODWAOHHSA-N | ||
Standard InChI | InChI=1S/C22H28N2O3/c1-4-14-12-24-10-9-16-15-7-5-6-8-19(15)23-21(16)20(24)11-17(14)18(13-26-2)22(25)27-3/h5-8,13-14,17,20,23H,4,9-12H2,1-3H3/b18-13+/t14-,17?,20?/m0/s1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | 1. Dihydrocorynantheine exhibits significant vasodilating activity against phenylephrine-induced contraction in rat thoracic aorta rings (IC(50) = 6.73 μg/mL), it also shows weak inhibitory action on KCl-induced contraction. 2. Dihydrocorynantheine shows pronounced activity against Leishmania major promastigotes (IC50 at the micromolar level) but no significant in vitro antiplasmodial activity (against chloroquinesensitive Plasmodium falciparum). |
Targets | Antifection |
Dihydrocorynantheine Dilution Calculator
Dihydrocorynantheine Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 2.7137 mL | 13.5685 mL | 27.137 mL | 54.2741 mL | 67.8426 mL |
5 mM | 0.5427 mL | 2.7137 mL | 5.4274 mL | 10.8548 mL | 13.5685 mL |
10 mM | 0.2714 mL | 1.3569 mL | 2.7137 mL | 5.4274 mL | 6.7843 mL |
50 mM | 0.0543 mL | 0.2714 mL | 0.5427 mL | 1.0855 mL | 1.3569 mL |
100 mM | 0.0271 mL | 0.1357 mL | 0.2714 mL | 0.5427 mL | 0.6784 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Picrinine
Catalog No.:BCN5518
CAS No.:4684-32-6
- Norscopolamine
Catalog No.:BCN3983
CAS No.:4684-28-0
- Orphenadrine Citrate
Catalog No.:BCC4572
CAS No.:4682-36-4
- Drimenol
Catalog No.:BCN7224
CAS No.:468-68-8
- Mesembrenone
Catalog No.:BCN3753
CAS No.:468-54-2
- Lupulon
Catalog No.:BCC8204
CAS No.:468-28-0
- Colupulone
Catalog No.:BCN8097
CAS No.:468-27-9
- Lu AE58054
Catalog No.:BCC1707
CAS No.:467459-31-0
- Lu AE58054 Hydrochloride
Catalog No.:BCC1708
CAS No.:467458-02-2
- Nootkatone
Catalog No.:BCN5517
CAS No.:4674-50-4
- Diphenyleneiodonium chloride
Catalog No.:BCC6670
CAS No.:4673-26-1
- 17-DMAG (Alvespimycin) HCl
Catalog No.:BCC1175
CAS No.:467214-21-7
- 3-Benzofurancarboxaldehyde
Catalog No.:BCC8622
CAS No.:4687-25-6
- Cimilactone A
Catalog No.:BCN7948
CAS No.:468733-06-4
- BMS-536924
Catalog No.:BCC1177
CAS No.:468740-43-4
- Hamamelitannin
Catalog No.:BCC8182
CAS No.:469-32-9
- Cycloeucalenol
Catalog No.:BCN5519
CAS No.:469-39-6
- Jervine
Catalog No.:BCN2975
CAS No.:469-59-0
- 5'-IMPdisodium salt
Catalog No.:BCN8175
CAS No.:4691-65-0
- Carbenicillin
Catalog No.:BCC5192
CAS No.:4697-36-3
- Uncarine D
Catalog No.:BCC8262
CAS No.:4697-68-1
- Isoalantolactone
Catalog No.:BCN4955
CAS No.:470-17-7
- Cinobufagin
Catalog No.:BCN5367
CAS No.:470-37-1
- Marinobufagin
Catalog No.:BCC9238
CAS No.:470-42-8
Macrophyllionium and macrophyllines A and B, oxindole alkaloids from Uncaria macrophylla.[Pubmed:21070010]
J Nat Prod. 2011 Jan 28;74(1):12-5.
An unusual oxindole alkaloid inner salt, macrophyllionium (1), and a pair of new tetracyclic oxindole alkaloids, macrophyllines A (2) and B (3), together with six known alkaloids, were isolated from the aerial parts of Uncaria macrophylla. Corynantheidine (8) exhibited moderate cytotoxicity against HL-60 and SW480 cells with IC(50) values of 13.96 and 23.28 muM, respectively. Dihydrocorynantheine (9) exhibited significant vasodilating activity against phenylephrine-induced contraction in rat thoracic aorta rings (IC(50) = 6.73 mug/mL). In addition, compounds 2, 6, and 9 showed weak inhibitory action on KCl-induced contraction.