Uncarine DCAS# 4697-68-1 |
- Isomitraphylline
Catalog No.:BCN7800
CAS No.:4963-01-3
- Mitraphylline
Catalog No.:BCC8213
CAS No.:509-80-8
- Uncarine E
Catalog No.:BCC8263
CAS No.:5171-37-9
- Uncarine C
Catalog No.:BCC8261
CAS No.:5629-60-7
- Uncarine A
Catalog No.:BCN7767
CAS No.:6899-73-6
- Uncarine F
Catalog No.:BCN9446
CAS No.:14019-66-0
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 4697-68-1 | SDF | Download SDF |
PubChem ID | 168985 | Appearance | Powder |
Formula | C21H24N2O4 | M.Wt | 368.4 |
Type of Compound | N/A | Storage | Desiccate at -20°C |
Synonyms | Speciophylline | ||
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | methyl (1S,4aS,5aR,6S,10aS)-1-methyl-2'-oxospiro[1,4a,5,5a,7,8,10,10a-octahydropyrano[3,4-f]indolizine-6,3'-1H-indole]-4-carboxylate | ||
SMILES | CC1C2CN3CCC4(C3CC2C(=CO1)C(=O)OC)C5=CC=CC=C5NC4=O | ||
Standard InChIKey | JMIAZDVHNCCPDM-ZUNJVLJPSA-N | ||
Standard InChI | InChI=1S/C21H24N2O4/c1-12-14-10-23-8-7-21(16-5-3-4-6-17(16)22-20(21)25)18(23)9-13(14)15(11-27-12)19(24)26-2/h3-6,11-14,18H,7-10H2,1-2H3,(H,22,25)/t12-,13-,14-,18+,21-/m0/s1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Uncarine D Dilution Calculator
Uncarine D Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 2.7144 mL | 13.5722 mL | 27.1444 mL | 54.2888 mL | 67.861 mL |
5 mM | 0.5429 mL | 2.7144 mL | 5.4289 mL | 10.8578 mL | 13.5722 mL |
10 mM | 0.2714 mL | 1.3572 mL | 2.7144 mL | 5.4289 mL | 6.7861 mL |
50 mM | 0.0543 mL | 0.2714 mL | 0.5429 mL | 1.0858 mL | 1.3572 mL |
100 mM | 0.0271 mL | 0.1357 mL | 0.2714 mL | 0.5429 mL | 0.6786 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Carbenicillin
Catalog No.:BCC5192
CAS No.:4697-36-3
- 5'-IMPdisodium salt
Catalog No.:BCN8175
CAS No.:4691-65-0
- Jervine
Catalog No.:BCN2975
CAS No.:469-59-0
- Cycloeucalenol
Catalog No.:BCN5519
CAS No.:469-39-6
- Hamamelitannin
Catalog No.:BCC8182
CAS No.:469-32-9
- BMS-536924
Catalog No.:BCC1177
CAS No.:468740-43-4
- Cimilactone A
Catalog No.:BCN7948
CAS No.:468733-06-4
- 3-Benzofurancarboxaldehyde
Catalog No.:BCC8622
CAS No.:4687-25-6
- Dihydrocorynantheine
Catalog No.:BCN3747
CAS No.:4684-43-9
- Picrinine
Catalog No.:BCN5518
CAS No.:4684-32-6
- Norscopolamine
Catalog No.:BCN3983
CAS No.:4684-28-0
- Orphenadrine Citrate
Catalog No.:BCC4572
CAS No.:4682-36-4
- Isoalantolactone
Catalog No.:BCN4955
CAS No.:470-17-7
- Cinobufagin
Catalog No.:BCN5367
CAS No.:470-37-1
- Marinobufagin
Catalog No.:BCC9238
CAS No.:470-42-8
- Stachyose tetrahydrate
Catalog No.:BCC8252
CAS No.:470-55-3
- 1-Kestose
Catalog No.:BCN8292
CAS No.:470-69-9
- Cineole
Catalog No.:BCN2686
CAS No.:470-82-6
- Benzoyl-DL-methionine
Catalog No.:BCC8863
CAS No.:4703-38-2
- Beta-Lapachone
Catalog No.:BCC5088
CAS No.:4707-32-8
- alpha-Lapachone
Catalog No.:BCN5520
CAS No.:4707-33-9
- Atraric acid
Catalog No.:BCN5521
CAS No.:4707-47-5
- 8-Amino-7-oxononanoic acid
Catalog No.:BCN1778
CAS No.:4707-58-8
- Glycyrrhetinic acid
Catalog No.:BCN5942
CAS No.:471-53-4
Investigation of Una De Gato I. 7-Deoxyloganic acid and 15N NMR spectroscopic studies on pentacyclic oxindole alkaloids from Uncaria tomentosa.[Pubmed:11397448]
Phytochemistry. 2001 Jul;57(5):781-5.
The C-8-(S) isomer of deoxyloganic acid (7-deoxyloganic acid), together with beta-sitosteryl glucoside, five known stereoisomeric pentacyclic oxindole alkaloids and the tetracyclic oxindole isorhyncophylline, were isolated from the inner bark of Uncaria tomentosa. Structures of the isolated compounds were based on 1H and 13C NMR data, mainly 2D NMR experiments, including 1H-13C HMBC and 1H-1H NOESY correlation. Furthermore, the hitherto unreported 15N chemical shifts of the isomeric oxindole alkaloids, using 1H-15N HMBC experiments, were utilized to facilitate their characterization. Uncarine D showed weak cytotoxic activity against SK-MEL, KB, BT-549 and SK-OV-3 cell lines with IC(50) values between 30 and 40 microg/ml, while uncarine C exhibited weak cytotoxicity only against ovarian carcinoma (IC(50) at 37 microg/ml).
High-performance liquid chromatographic method for the quantification of Mitragyna inermis alkaloids in order to perform pharmacokinetic studies.[Pubmed:20437411]
J Sep Sci. 2010 Jun;33(12):1863-9.
In Africa, Mitragyna inermis (Willd.) O. Kuntze (Rubiaceae) is commonly used in traditional medicine to treat malaria. Antimalarial activity is mostly due to the hydromethanolic extract of M. inermis leaves and especially to the main alkaloids, Uncarine D and isorhynchophilline. In the present study, we describe for the first time an HPLC method for the simultaneous quantification of Uncarine D and isorhynchophylline in biological matrices. SPE was used to extract the components and the internal standard naphthalene from human and pig plasma samples. Chromatographic separation was performed on a C-18 reversed column at a flow rate of 1 mL/min, using methanol-phosphate buffer (10:90, pH 7), as a mobile phase. Good linearity was observed over the concentration ranges of 0.0662-3.31 microg/mL for Uncarine D and 0.0476-2.38 microg/mL for isorynchophylline. The precision was less than 12% and the accuracy was from 86 to 107% without any discrepancy between the two species. Uncarine D and isorhynchophylline recoveries were over 80%. These results allowed the quantification of both Uncarine D and isorhynchophylline in pig plasma after intravenous administration of M. inermis extract.