Products with Anti-leishmanial bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN4896 | Parthenolide |
| Parthenolide exhibits anti-cancer, anti-inflammatory, immunomodulatory, anti-Leishmania, and antimigraine effects, it inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel.Parthenolide is also an inhibitor of the nuclear factor-kappaB pathway, can ameliorate cardiovascular derangement and outcome in endotoxic shock in rodents. | |
| BCN5159 | alpha-Hederin |
| alpha-Hederin possesses several biological properties such as antispasmodic, moliscicidic, anthelmithic and inhibiting cell proliferation, it exhibits a strong antiproliferative activity on all stages of development of the parasite by altering membrane integrity and potential in Leishmania. alpha-Hederin has anti-oxidant activity and acute anti-inflammatory activity in carrageenan-induced rat paw edema. alpha-Hederin can increase isoprenaline-induced relaxation indirectly, probably by inhibiting heterologous desensitization induced by high concentrations of muscarinic ligands like. | |
| BCN5218 | Harmaline |
| Harmaline is a central nervous system stimulant and an acetylcholinesterase (AChR) inhibitor; also inhibits histamine N-methyltransferase. Harmaline has antileishmanial, bioinsecticidal, and vasorelaxant effects. It has antagonist effects on alpha1-adrenorecepteors in non-competitive manner, it also exerts an antioxidant activity by scavenging the free radical generated by DPPH.Harmaline may prevent dopamine-induced mitochondrial damage and PC12 cell death through a scavenging action on reactive oxygen species and inhibition of monoamine oxidase and thiol oxidation. | |
| BCN5277 | Lyoniside |
| 1. Lyoniside and saracoside are cytotoxic to promastigotes and intracellular amastigotes, they demonstrate strong anti-leishmanial efficacies in BALB/c mice model of leishmaniasis, suggests that these two compounds potential anti-leishmanial candidates. 2. The synergistic action of lyoniside and triterpene acids was demonstrated in inhibitory effect exerted on germination and growth of Pinus sylvestris . | |
| BCN5347 | Calceolarioside A |
| 1. Calceolarioside A shows potent activity against visceral leishmaniasis. 2. Calceolarioside A can induce a dose-related aggregant effect on rabbit platelets, which may be partly related to a calcium-dependent mechanism. 3. Calceolarioside A has potent antioxidative activity, it displays stronger scavenging potential with IC50 values of (4.15 +/- 0.07, 40.32 +/- 0.09, 2.26 +/- 0.03 microM) for OH, total ROS and scavenging of ONOO(-), respectively. | |
