Products with Anti-leishmanial bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN6062 | Cuniloside B |
| 1. Cuniloside B shows anti-leishmanial activity. | |
| BCN6339 | Linalool |
| Linalool, is a competitive antagonist of NMDA receptors, which has anti-inflammatory, antinociceptive, anti-anxiety, local anaesthetic, anti-leishmanicidal, and insecticidal properties. Linalool has dose-dependent marked sedative effects at the central nervous system (CNS), including hypnotic, anticonvulsant and hypothermic properties, it also has an inhibitory effect on the acetylcholine (ACh) release and on the channel open time in the mouse neuromuscular junction. The purified linalool fraction is only inhibitory for C. albicans. | |
| BCN6523 | Lysicamine |
| 1. Lysicamine has antimicrobial and anti-inflammation activity, the minimum inhibitory concentrations of the pour component (Streptococcus mutans, Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans and Candida albicans.) is less than 5mg/ml for all four microorganisms and the minimum concentration with anti-inflammation is 0.2mg/ml for both IL-8 and IL-6. 2. Lysicamine has antileishmanial activity. 3. Lysicamine shows significant antioxidant capacity in the ORAC(FL) assay and it is active against S. epidermidis and C. dubliniensis, with MIC values in the range 12.5-100 microg mL(-1). 4. Lysicamine can significantly inhibit the proliferation of melanoma cells, it has antioxidative activity and chemopreventive activity in skin melanoma cells. | |
| BCN6553 | Hederacolchiside A1 |
| 1. Hederacolchiside A1 shows antiproliferation activities in three cancer cell lines with the IC50 value of 2.4 uM. 2. Hederacolchiside A1 has antimelanoma potential. 3. Hederacolchiside A1 exhibits a preferential cytotoxicity on a pigmented melanoma cell line. 4. Hederacolchiside A1 shows anti-leishmanial activity, it exhibits a strong antiproliferative activity on all stages of development of the parasite by altering membrane integrity and potential. | |
| BCN6680 | 2,3-Dihydrohinokiflavone |
| 1. 2,3-Dihydrohinokiflavone (IC50 =1.6uM) shows strong activity against Leishmania. 2. 2,3-Dihydrohinokiflavone is a suppressor of matrix metalloproteinases (MMPs) gene expression. | |
