Products with Anti-melanogenic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN3462 | Trans-caffeic acid |
| 1. Trans-caffeic acid stearyl ester is posited to inhibit melanogenesis signaling while suppressing cAMP levels and, subsequently, MC1R, MITF, tyrosinase, TRP-2 and TRP-1 down-regulation, resulting in the suppression of tyrosinase activity, DOPA oxidase activity and melanin synthesis. | |
| BCN3509 | Britannilactone |
| 1. Britannilactone significantly reduces melanin production in a dose-dependent manner with the IC50 value of 15.5 uM. | |
| BCN3825 | 2,5-Dihydroxyacetophenone |
| 2,5-Dihydroxyacetophenone is an uncompetitive inhibitor of murine tyrosinase (K(I) 0.28mm), it strongly inhibits both melanogenesis and cellular tyrosinase activity, it possesses anti-inflammatoryanti-anxiety, and neuroprotective qualities. 2,5-Dihydroxyacetophenone treatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPKs, it also can potentiate the pro-apoptotic and anti-proliferative effects of bortezomib in U266 cells. | |
| BCN3921 | Haplopine |
| 1. Haplopine shows photo-activated antimicrobial activity against S. aureus. 2. Haplopine exhibits potent melanogenesis-inhibitory activities with almost no toxicity to the cells. | |
| BCN3927 | Dodoviscin A |
| 1. Dodoviscin A can inhibit melanin biosynthesis induced by 3-isobutyl-1-methylxanthine and PD98059, it may be a new promising pigmentation-altering agent for cosmetic and therapeutic applications. 2. Dodoviscin A can promote adipocyte differentiation as characterized by increased triglyceride levels in 3T3L1 cells. 3. Dodoviscin A can enhance the accumulation of lipid droplets and induce upregulation of the expression of the adipocyte-specific genes aP2 and GLUT4. | |
