Products with Anti-melanogenic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN6343 | Mulberroside A |
| Mulberroside A, the major active anti-tyrosinase compound in the root bark extract of Morus alba L. (Moraceae), is widely employed as an active ingredient in whitening cosmetics. Mulberroside A has neuroprotective, analgesic, anti-inflammatory, antiapoptotic, uricosuric, nephroprotective, hypoglycemic, and antidiabetic effects.It also can protect mice against ethanol-induced hepatic damage. | |
| BCN6524 | Cepharadione B |
| 1. Cepharadione B exhibits strong tyrosinase inhibitory activity with an IC50 value of 170 microM. 2. Cepharadione B exhibits significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15) in vitro. | |
| BCN6611 | Torilin |
| 1. Torilin has anti-inflammatory properties, it inhibits inflammation by limiting TAK1-mediated MAP kinase and NF-κB activation. 2. Torilin can attenuate arthritis severity, modify leukocyte activations in dLNs or joints, and restore serum and splenocyte cytokine imbalances, it may have immunomodulatory and anti-inflammatory properties with the capacity to ameliorate the inflammatory response in collagen-induced-arthritis-(CIA)-mice. 3. Torilin inhibits melanin production in alpha-melanocyte stimulating hormone-activated B16 melanoma cells, with an IC(50) value of 25 microM. 4. Torilin shows excellent antimicrobial activity against Bacillus subtilis ATCC 6633 spores and vegetative cells, it functions as a surfactant with hydrophilic and hydrophobic properties related to denaturalization of various proteins,the distortion of coat proteins due to direct binding polar groups of spore coats with hydrophilic groups of torilin may be responsible for the observed rapid inactivation of bacterial spores. 5. Torilin has a potent anti-angiogenic activity both in vivo and in vitro, and it may have a strong activity to suppress tumorigenesis by inhibition of tumor invasion. 6. Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic acid (IC50 = 160.3 +/- 24.62 microM) but is weaker than finasteride (IC50 = 0.38 +/- 0.06 microM). 7. Torilin reverses multidrug-resistance in cancer cells, it can potentiate the cytotoxicities of adriamycin, vinblastine, taxol and colchicine against multidrug-resistant KB-V1 and MCF7/ADR cells. 8. Torilin and torilolone show hepatoprotective effects on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells, the EC50 values are 20.6 +/- 1.86 and 3.6 +/- 0.1 microM, respectively; and silybin as a positive control shows an EC50 value of 69.0 +/- 3.4 microM. | |
| BCN6692 | Glabrene |
| Glabrene, Liquiritin apioside, neolicuroside, and 18β-glycyrrhetic acid are the predominant phenolic derivatives partitioning at the interface and most likely the major contributors to the notable synergistic antioxidant activity when coupled with pea protein hydrolysates (PPHs).Glabrene has estrogen-like activity, it can stimulate DNA synthesis in human endothelial cells (ECV-304; E304) and has a bi-phasic effect on proliferation of human vascular smooth muscle cells (VSMC). Glabrene and isoliquiritigenin may serve as candidates for skin-lightening agents, they exert varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis. | |
| BCN8184 | Pulsatilla camphor |
| 1. Pulsatilla saponin D exhibits anticancer activities in various cancer types, it Inhibits autophagic flux and synergistically enhances the anticancer activity of chemotherapeutic agents against HeLa cells. 2. Pulsatilla saponin D has strong haemolytic activity. | |
