Products with Anticancer bioactivity

Cat.No. Product Name
BCN3606 (-)-beta-Peltatin
1. (-)-beta-Peltatin has antimitotic, and antineoplastic activities.
BCN3610 3-Hydroxybakuchiol
3-Hydroxybakuchiol exerts cytotoxic and anti-proliferative effects on the TA3/Ha mouse mammary adenocarcinoma cell line and induces a decrease in the mitochondrial transmembrane potential, the activation of caspase-3, the opening of the mitochondrial permeability transport pore (MPTP) and nuclear DNA fragmentation.3-Hydroxybakuchiol has antitumor activity resulting from interactions with the ETC, a system that is already deficient in cancer cells.
BCN3618 (±)-Marmesin
Marmesin has hepatoprotective potential; it also has cytotoxic with a 50% lethal dose of less than 0.5 micrograms/ml, is not as mutagenic or potentially carcinogenic as are AFB1, imperatorin, or MOP with BL activation.
BCN3645 Polyporenic acid C
1. Polyporenic acid C shows inhibitory activity against human collagenase. 2. Polyporenic acid C induces apoptosis through the death receptor-mediated apoptotic pathway where the activation of caspase-8 leads to the direct cleavage of execution caspases without the involvement of the mitochondria.
BCN3646 Dehydroeburicoic acid
1. Dehydroeburicoic acid treatment resulted in a marked decrease of tumor weight and size without any significant decrease in mice body weights. 2. Dehydroeburicoic acid induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation in human glioblastomas. 3. Dehydroeburicoic acid and Eburicoic acid have antioxidant and anti-inflammatory activities by the decrease of inflammatory cytokines and an increase of antioxidant enzyme activity, can protect the liver from CCl4-induced hepatic damage.

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