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(-)-beta-Peltatin

CAS# 518-29-6

(-)-beta-Peltatin

Catalog No. BCN3606----Order now to get a substantial discount!

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Quality Control of (-)-beta-Peltatin

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Chemical structure

(-)-beta-Peltatin

3D structure

Chemical Properties of (-)-beta-Peltatin

Cas No. 518-29-6 SDF Download SDF
PubChem ID 92122 Appearance Powder
Formula C22H22O8 M.Wt 414.4
Type of Compound Lignans Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (5aR,8aR,9R)-4-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one
SMILES COC1=CC(=CC(=C1OC)OC)C2C3C(CC4=C(C5=C(C=C24)OCO5)O)COC3=O
Standard InChIKey HLBPOYVRLSXWJJ-PDSMFRHLSA-N
Standard InChI InChI=1S/C22H22O8/c1-25-14-5-10(6-15(26-2)20(14)27-3)17-12-7-16-21(30-9-29-16)19(23)13(12)4-11-8-28-22(24)18(11)17/h5-7,11,17-18,23H,4,8-9H2,1-3H3/t11-,17+,18-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of (-)-beta-Peltatin

The herbs of Podophyllum peltatum

Biological Activity of (-)-beta-Peltatin

Description1. (-)-beta-Peltatin has antimitotic, and antineoplastic activities.

(-)-beta-Peltatin Dilution Calculator

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(-)-beta-Peltatin Molarity Calculator

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Preparing Stock Solutions of (-)-beta-Peltatin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4131 mL 12.0656 mL 24.1313 mL 48.2625 mL 60.3282 mL
5 mM 0.4826 mL 2.4131 mL 4.8263 mL 9.6525 mL 12.0656 mL
10 mM 0.2413 mL 1.2066 mL 2.4131 mL 4.8263 mL 6.0328 mL
50 mM 0.0483 mL 0.2413 mL 0.4826 mL 0.9653 mL 1.2066 mL
100 mM 0.0241 mL 0.1207 mL 0.2413 mL 0.4826 mL 0.6033 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on (-)-beta-Peltatin

Formation of beta-peltatin-A methyl ether and coniferin by root cultures of Linum flavum.[Pubmed:3760883]

J Nat Prod. 1986 May-Jun;49(3):435-9.

Extracts of root cultures of Linum flavum contained high cytotoxic activity due to the presence of 1% beta-peltatin-A methyl ether of the dry mass. During chromatographic analysis of the cell extracts, coniferin was identified as the major uv-absorbing but noncytotoxic constituent with levels of up to 3% of the dry mass. Growth, culture appearance, and product accumulation varied greatly with the 2,4-D concentration in the medium.

First synthesis and pharmacological evaluation of benzoindolizidine and benzoquinolizidine analogues of alpha- and beta-peltatin.[Pubmed:11003157]

Bioorg Med Chem. 2000 Aug;8(8):2113-25.

The benzoindolizidine and quinolizidine analogues of alpha- and beta-peltatin were designed and synthesized by two different synthetic routes involving as the key step the Bischler-Napieralski cyclization of suitably substituted N-acyl-2-arylmethylpyrrolidine and -piperidine derivatives. The in vitro biological activity of these analogues as well as some of their derivatives was subsequently evaluated.

Beta-peltatin 6-O-methyltransferase from suspension cultures of Linum nodiflorum.[Pubmed:12943762]

Phytochemistry. 2003 Sep;64(2):453-8.

S-Adenosyl-L-methionine:beta-peltatin 6-O-methyltransferase was isolated and characterized from cell suspension cultures of Linum nodiflorum L. (Linaceae), a Linum species accumulating aryltetralin lignans such as 6-methoxypodophyllotoxin. The enzyme transfers a methyl group from S-adenosyl-L-methionine to the only free OH-group of beta-peltatin in position 6 thus forming beta-peltatin-A methylether. This reaction is a putative biosynthetic step in the biosynthesis of 6-methoxypodophyllotoxin from deoxypodophyllotoxin. The enzyme has a pH-optimum at pH 7.7 and a temperature optimum at 40 degrees C. The enzyme activity is strongly inhibited by MnSO(4), FeCl(3), FeSO(4) and ZnSO(4) as well as S-adenosyl-homocysteine. Mg(2+) and EDTA did not influence the methylation of beta-peltatin. Substrate saturation curves were obtained for S-adenosyl-methionine and beta-peltatin and apparent K(m)-values of 15 microM and 40 microM, respectively, were determined for these substrates. Substrate inhibition was observed for beta-peltatin. No other lignan substrate tested nor caffeic acid were accepted. The suspension cell line of Linum nodiflorum was characterized with respect to growth, medium alterations and lignan production as well as activity of SAM:beta-peltatin 6-O-methyltransferase. Highest specific activities of beta-peltatin 6-O-methyltransferase were determined on day 7 of the culture period corresponding to the highest levels of 6-methoxypodophyllotoxin on days 7 to 12.

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