XanthopurpurinCAS# 518-83-2 |
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| Cas No. | 518-83-2 | SDF | Download SDF |
| PubChem ID | 196978 | Appearance | Yellow powder |
| Formula | C14H8O4 | M.Wt | 240.21 |
| Type of Compound | Anthraquinones | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 1,3-dihydroxyanthracene-9,10-dione | ||
| SMILES | C1=CC=C2C(=C1)C(=O)C3=CC(=CC(=C3C2=O)O)O | ||
| Standard InChIKey | WPWWKBNOXTZDQJ-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C14H8O4/c15-7-5-10-12(11(16)6-7)14(18)9-4-2-1-3-8(9)13(10)17/h1-6,15-16H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Xanthopurpurin may can effectively inhibit rotavirus multiplication by promoting virus-induced apoptosis in MA-104 cells. 2. Xanthopurpurin shows mainly strong inhibition of collagen-induced platelet aggregation. |
| Targets | Antifection |
Xanthopurpurin Dilution Calculator
Xanthopurpurin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.163 mL | 20.8151 mL | 41.6302 mL | 83.2605 mL | 104.0756 mL |
| 5 mM | 0.8326 mL | 4.163 mL | 8.326 mL | 16.6521 mL | 20.8151 mL |
| 10 mM | 0.4163 mL | 2.0815 mL | 4.163 mL | 8.326 mL | 10.4076 mL |
| 50 mM | 0.0833 mL | 0.4163 mL | 0.8326 mL | 1.6652 mL | 2.0815 mL |
| 100 mM | 0.0416 mL | 0.2082 mL | 0.4163 mL | 0.8326 mL | 1.0408 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Antiplatelet constituents of formosan Rubia akane.[Pubmed:8176404]
J Nat Prod. 1994 Feb;57(2):313-6.
A known steroid, in addition to triterpenoids, anthraquinones, naphthalenes and a new anthraquinone glycoside, Xanthopurpurin 3-O-beta-D-glucoside, were isolated from the roots of Rubia akane grown in Taiwan. Mollugin, a naphthohydroquinone, showed strong inhibition of arachidonic acid (AA)-induced and collagen-induced platelet aggregation. In contrast, 2-methyl-1,3,6-trihydroxyl-9,10-anthraquinone, Xanthopurpurin 3-O-beta-D-glucoside, and Xanthopurpurin showed mainly strong inhibition of collagen-induced platelet aggregation.
In vitro Antiviral Activity of Rubia cordifolia Aerial Part Extract against Rotavirus.[Pubmed:27679574]
Front Pharmacol. 2016 Sep 13;7:308.
The root of Rubia cordifolia has been used traditionally as a hemostatic agent, while the aerial part of the plant consisting of leaf and stem is known to exhibit anti-diarrheal properties and has been widely used as a remedy in many parts of China. As rotavirus is one of the most commonly associated diarrhea-causing pathogen, this study aims to investigate the anti-rotaviral effect of R. cordifolia aerial part (RCAP). The cytotoxicity of RCAP toward MA-104 cells was evaluated using the WST-8 assay. Colloidal gold method and real time polymerase chain reaction (qPCR) assay were used to confirm the findings of the antiviral assay. Then, 4',6-diamidino-2-phenylindole (DAPI) staining method was subsequently used to investigate the mode of death among the cells. And the representative components of aqueous extract were isolated and identified. It was shown that both the viability of MA-104 cells and the viral load were reduced with increasing concentration of the extract. DAPI staining showed that virus-induced apoptosis was the cause of the low cell viability and viral load, an effect which was accelerated with incubation in the aqueous herbal extract. The major compounds postulated to exhibit this activity were isolated from the aqueous herbal extract and identified to be compounds Xanthopurpurin and Vanillic Acid. This study showed that RCAP extract effectively inhibited rotavirus multiplication by promoting virus-induced apoptosis in MA-104 cells.
