2',4'-DihydroxychalconeCAS# 1776-30-3 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 1776-30-3 | SDF | Download SDF |
| PubChem ID | 5376979 | Appearance | Yellow powder |
| Formula | C15H12O3 | M.Wt | 240.26 |
| Type of Compound | Chalcones | Storage | Desiccate at -20°C |
| Synonyms | (E)-2',4'-Dihydroxychalcone | ||
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (E)-1-(2,4-dihydroxyphenyl)-3-phenylprop-2-en-1-one | ||
| SMILES | C1=CC=C(C=C1)C=CC(=O)C2=C(C=C(C=C2)O)O | ||
| Standard InChIKey | JUMSUVHHUVPSOY-RMKNXTFCSA-N | ||
| Standard InChI | InChI=1S/C15H12O3/c16-12-7-8-13(15(18)10-12)14(17)9-6-11-4-2-1-3-5-11/h1-10,16,18H/b9-6+ | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The roots of Glycyrrhiza glabra L.
2',4'-Dihydroxychalcone Dilution Calculator
2',4'-Dihydroxychalcone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.1622 mL | 20.8108 mL | 41.6216 mL | 83.2432 mL | 104.0539 mL |
| 5 mM | 0.8324 mL | 4.1622 mL | 8.3243 mL | 16.6486 mL | 20.8108 mL |
| 10 mM | 0.4162 mL | 2.0811 mL | 4.1622 mL | 8.3243 mL | 10.4054 mL |
| 50 mM | 0.0832 mL | 0.4162 mL | 0.8324 mL | 1.6649 mL | 2.0811 mL |
| 100 mM | 0.0416 mL | 0.2081 mL | 0.4162 mL | 0.8324 mL | 1.0405 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Featured Products
- KX1-004
Catalog No.:BCC5440
CAS No.:518058-84-9
- Raltegravir (MK-0518)
Catalog No.:BCC2137
CAS No.:518048-05-0
- Dihydrooxoepistephamiersine
Catalog No.:BCN5646
CAS No.:51804-69-4
- Oxoepistephamiersine
Catalog No.:BCN5645
CAS No.:51804-68-3
- Nimesulide
Catalog No.:BCC4435
CAS No.:51803-78-2
- 3,3'-Di-O-methylellagic acid 4'-glucoside
Catalog No.:BCN1431
CAS No.:51803-68-0
- Isomaculosidine
Catalog No.:BCN7069
CAS No.:518-96-7
- Cycleanine
Catalog No.:BCN8445
CAS No.:518-94-5
- Xanthopurpurin
Catalog No.:BCN6723
CAS No.:518-83-2
- Emodin
Catalog No.:BCN5649
CAS No.:518-82-1
- Corydaline
Catalog No.:BCN2342
CAS No.:518-69-4
- Tetrandrine
Catalog No.:BCN5955
CAS No.:518-34-3
New Products
- UMI-77
Catalog No.:BCC5567
CAS No.:518303-20-3
- Angiotensin 1/2 + A (2 - 8)
Catalog No.:BCC1037
CAS No.:51833-76-2
- Angiotensin (1-7)
Catalog No.:BCC1029
CAS No.:51833-78-4
- 3-MATIDA
Catalog No.:BCC7281
CAS No.:518357-51-2
- Allamandicin
Catalog No.:BCN4625
CAS No.:51838-83-6
- Licoricone
Catalog No.:BCN6818
CAS No.:51847-92-8
- 7-O-Methyleriodictyol
Catalog No.:BCN5648
CAS No.:51857-11-5
- Axillarin
Catalog No.:BCN8102
CAS No.:5188-73-8
- Pizotifen Malate
Catalog No.:BCC4825
CAS No.:5189-11-7
- Matrine
Catalog No.:BCN5650
CAS No.:519-02-8
- Benzoylecgonine
Catalog No.:BCN1909
CAS No.:519-09-5
- Ellipticine
Catalog No.:BCC7665
CAS No.:519-23-3
In Vitro Antifungal Activity and Mode of Action of 2',4'-Dihydroxychalcone against Aspergillus fumigatus.[Pubmed:26190922]
Mycobiology. 2015 Jun;43(2):150-6.
2',4'-Dihydroxychalcone (2',4'-DHC) was identified from a heat shock protein 90 (Hsp90)-targeting library as a compound with Hsp90 inhibitory and antifungal effects. In the presence of 2',4'-DHC (8 microg/mL), radial growth of Aspergillus fumigatus was inhibited 20% compared to the control, and green pigmentation was completely blocked. The expression of the conidiation-associated genes abaA, brlA, and wetA was significantly decreased (approximately 3- to 5-fold) by treatment with 2',4'-DHC. The expression of calcineurin signaling components, cnaA and crzA, was also significantly reduced. The inhibitory effects of 2',4'-DHC on metabolic activity and mycelial growth were significantly enhanced by combination treatment with itraconazole and caspofungin. Docking studies indicated that 2',4'-DHC bind to the ATPase domain of Hsp90. These results suggest that 2',4'-DHC act as an Hsp90-calcinurin pathway inhibitor.
2',4'-Dihydroxychalcone,1776-30-3,(E)-2',4'-Dihydroxychalcone,Natural Products, buy 2',4'-Dihydroxychalcone , 2',4'-Dihydroxychalcone supplier , purchase 2',4'-Dihydroxychalcone , 2',4'-Dihydroxychalcone cost , 2',4'-Dihydroxychalcone manufacturer , order 2',4'-Dihydroxychalcone , high purity 2',4'-Dihydroxychalcone
