LicoriconeCAS# 51847-92-8 |
Quality Control & MSDS
3D structure
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Number of papers citing our products
| Cas No. | 51847-92-8 | SDF | Download SDF |
| PubChem ID | 5319013 | Appearance | Powder |
| Formula | C22H22O6 | M.Wt | 382.41 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 7-hydroxy-3-[6-hydroxy-2,4-dimethoxy-3-(3-methylbut-2-enyl)phenyl]chromen-4-one | ||
| SMILES | CC(=CCC1=C(C=C(C(=C1OC)C2=COC3=C(C2=O)C=CC(=C3)O)O)OC)C | ||
| Standard InChIKey | GGWMNTNDTRKETA-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C22H22O6/c1-12(2)5-7-15-18(26-3)10-17(24)20(22(15)27-4)16-11-28-19-9-13(23)6-8-14(19)21(16)25/h5-6,8-11,23-24H,7H2,1-4H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Licoricone exhibits anti-helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains. |
| Targets | Antifection |
Licoricone Dilution Calculator
Licoricone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.615 mL | 13.075 mL | 26.1499 mL | 52.2999 mL | 65.3749 mL |
| 5 mM | 0.523 mL | 2.615 mL | 5.23 mL | 10.46 mL | 13.075 mL |
| 10 mM | 0.2615 mL | 1.3075 mL | 2.615 mL | 5.23 mL | 6.5375 mL |
| 50 mM | 0.0523 mL | 0.2615 mL | 0.523 mL | 1.046 mL | 1.3075 mL |
| 100 mM | 0.0261 mL | 0.1307 mL | 0.2615 mL | 0.523 mL | 0.6537 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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[Chemical studies of coumarins from Glycyrrhiza uralensis Fisch].[Pubmed:1950571]
Yao Xue Xue Bao. 1991;26(2):147-51.
This paper reports the isolation and identification of eight crystalline substances (I, II, III, IV, V, VI, VII, VIII) from the root of Glycyrrhiza uralensis Fisch. Besides the known compounds liquiritin, hexacosance, beta-sitosterol, Licoricone liquiritigenin and etc, a new constituent, named neoglycyrol was obtained by sillica gel and polyamide column chromatographic method. Its chemical structure was elucidated by means of chemical and spectrometric analysis (UV, IR, NMR and MS). Neoglycyrol, C21H18O6, yellow needles with mp 263.5-265 degrees C, possesses one methoxyl, one isopentenyl and two hydroxyls. Its diacetate derivative is C25H22O8 with mp 202-203.5 degrees C. Its dimethyl ether derivative is C23H22O6 with mp 207-208.5 degrees C. Its structure was found to be VII.
Anti-Helicobacter pylori flavonoids from licorice extract.[Pubmed:12127165]
Life Sci. 2002 Aug 9;71(12):1449-63.
Licorice is the most used crude drug in Kampo medicines (traditional Chinese medicines modified in Japan). The extract of the medicinal plant is also used as the basis of anti-ulcer medicines for treatment of peptic ulcer. Among the chemical constituents of the plant, glabridin and glabrene (components of Glycyrrhiza glabra), licochalcone A (G. inflata), licoricidin and licoisoflavone B (G. uralensis) exhibited inhibitory activity against the growth of Helicobacter pylori in vitro. These flavonoids also showed anti-H. pylori activity against a clarithromycin (CLAR) and amoxicillin (AMOX)-resistant strain. We also investigated the methanol extract of G. uralensis. From the extract, three new isoflavonoids (3-arylcoumarin, pterocarpan, and isoflavan) with a pyran ring, gancaonols A[bond]C, were isolated together with 15 known flavonoids. Among these compounds, vestitol, Licoricone, 1-methoxyphaseollidin and gancaonol C exhibited anti-H. pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains. Glycyrin, formononetin, isolicoflavonol, glyasperin D, 6,8-diprenylorobol, gancaonin I, dihydrolicoisoflavone A, and gancaonol B possessed weaker anti-H. pylori activity. These compounds may be useful chemopreventive agents for peptic ulcer or gastric cancer in H. pylori-infected individuals.
