Products with Antimalaric bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN3128 | Isochamaejasmine |
| Isochamaejasmine has inhibition of NF-kappaB activation, which could reverse the anti-apoptotic effect; it induces apoptosis in leukemia cells by inhibiting the activity of Bcl-2 family proteins, providing evidence for further studying the underlying anti-cancer mechanism of S. chamaejasme L. Isochamaejasmine shows antiplasmodial activity, with an IC(50) of 7.3+/-3.8 microM, but the selectivity was rather limited. | |
| BCN3155 | Ferruginol |
| 1. Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic activities. 2. Ferruginol has cardioprotective, anti-oxidative and anti-inflammatory activities. 3. Ferruginol has anticancer activity, can induce apoptosis in non-small cell lung cancer (NSCLC) cells. 4. Ferruginol has antimicrobial and antifungal activities against wood-rot fungi (basidiomycetes), can cause cellular dysfunction and damage, lead to growth inhibition and autophagic cell death of fungi. | |
| BCN3156 | Methylenetanshinquinone |
| 1. Methylenetanshinquinone has antioxidative activity. 2. Methylenetanshinquinone ranges from 4.1 μM to over 30 μM against P. falciparum K1 strain with selectivity indices (SI) from 0.3 to 1.9. IC50s against T. brucei rhodesiense STIB 900 is from 0.5 μM (1, 4) to over 30 μM, shows the greatest selective activity with an SI of 24. | |
| BCN3264 | Terchebulin |
| 1. Terchebulin, flavogallonic acid and punicalagin have antiplasmodial activity, the IC50s of them range between 8-21 microg/ml (8-40 microM) against Plasmodium falciparum 3D7 and K1. 2. Terchebulin shows good antibacterial activity against Propionibacterium acnes, minimum inhibitory concentration (MIC) = 125 ug/ml and minimum bactericidal concentration (MBC) = 250 ug/ml, demonstrates that terchebulin has potentiality as an anti-acne agent. | |
| BCN3269 | Febrifugine |
| Febrifugine is an effective coccidiostat, possesses schizonticide props; it and its derivatives shows high degree of antimalarial activity but use limited by toxicity . | |
