Products with Antimalaric bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN3906 | 10-Hydroxycanthin-6-one |
| 1. 10-Hydroxycanthin-6-one has potential to be an antimicrobial agent. 2. 10-Hydroxycanthin-6-one has in vitro antimalarial activity. 3. 10-Hydroxycanthin-6-one has cytotoxic activity, it could be a plant anticancer agent. | |
| BCN4037 | Piplartine |
| 1. Piplartine shows potential anti-malaria and anti- leishmaniasis activities. 2. Piplartine shows inhibitory activities of platelet aggregation induced by ADP and AA in vitro . 3. Piplartine displays in vitro and in vivo anticancer efficacy. 4. Piplartine induces in vivo and in vitro mutagenicity in eukaryotic models. | |
| BCN4043 | Pellitorine |
| 1. Pellitorine shows strong cytotoxic activities against HL60 and MCT-7 cell lines. 2. Pellitorine can suppress expression of inducible NO synthase and cyclooxygenase-2. 3. Pellitorine shows antiprotozoal activity against Plasmodium falciparum (IC50 = 3.3 ug/mL). 4. Pellitorine is a potential larvicide with a specific target site and a lead molecule for the control of mosquito populations. 5. Pellitorine shows potent antiplatelet aggregation activity. | |
| BCN4115 | Chrysosplenetin |
| 1. Chrysosplenetin is a metabolic inhibitor of artemisinin. 2. Chrysosplenetin and penduletin have strong activity in vitro against EV71 with low cytotoxicity. 3. Co-administration of artemisinin(ART) with chrysosplenetin(CHR) in ratio of 1:2 achieved a synergic anti-malarial effect partly because of the noncompetitive or uncompetitive inhibition of CHR of drug-metabolism enzymes, especially CYP3A which is closely related to the auto-induction of ART. | |
| BCN4182 | Longistylin C |
| 1. Longistylin A and longistylin C show some cytotoxic effects, with IC(50) values of 0.7-14.7 microM against the range of cancer cell lines. 2. Longistylin A and longistylin C, and betulinic acid show a moderately high in vitro activity against the chloroquine-sensitive Plasmodium falciparum strain 3D7. | |
