Products with Antimalaric bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN2341 | Quinine |
| Quinine is an anti-malaria agent and also a potassium channel inhibitor with an IC50 of 169 μM.Quinine is used for the treatment of acute malaria in pregnant women. | |
| BCN2457 | Artesunate |
| Artesunate is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69. It is a potential inhibitor of STAT-3 and exhibits selective cytotoxicity of cancer cells over normal cells in vitro; A potent inhibitor of EXP1.Artesunate has anti-inflammatory activity, can prevent neuroinflammation in BV2 microglia by interfering with NF-κB and p38 MAPK signalling. | |
| BCN2477 | 1,2-Dihydrotanshinquinone |
| 1. 1,2 Dihydrotanshinquinone is active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum. | |
| BCN2507 | Lycorenine |
| 1. The development of tachyphylaxis to the vasodepressor action of lycorenine is ascribed to maintenance of its alpha-adrenergic blocking action. 2. Lycorenine may produce a decrease in blood pressure as the result of alpha-adrenergic blockade in conjunction with the reduction of the spontaneous sympathetic nerve activity, and produce bradycardia by modifying vagal activity. | |
| BCN2832 | Magnolioside |
| Magnolioside has anti-plasmodial activity, shows notable growth inhibitory activity against chloroquine-sensitive strains of P. falciparum. It also shows a moderate antibacterial activity against Staphylococcus aureus CIP 53.154. | |
