Products with Antimalaric bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN6077 | Coronarin B |
| 1. Coronarin B has cytotoxic activity. 2. Coronarin B has modest antiplasmodial activity. | |
| BCN6200 | Shikimic acid |
| Shikimic acid(Shikimate), more commonly known as its anionic form shikimate, is an important biochemical intermediate in plants and microorganisms, has great potential for the design and synthesis of enzyme inhibitors. It reversed the H2O2 induced oxidative damage in hepatocytes, probably through the inhibition of NF-κB, with the activation of PI3K/Akt/Nrf2 pathway and reduction of apoptosis by interfering the SAPK/JNK/Bax pathway; it also profoundly inhibited pancreatic lipase activity by 66%, thus providing another valuable therapeutic aspect for treating diet induced obesity in humans. | |
| BCN6204 | Oplodiol |
| 1. Oplodiol exhibits noteworthy anti-plasmodial activity against Plasmodium falciparum strains. 2. Oplodiol has a stimulative effect on significantly proliferation and differentiation of culture osteoblasts. 3. Oplodiol shows moderate cytotoxic effects on the human lung adenocarcinoma A549 with IC50 values at 25.5 ug/mL. | |
| BCN6264 | Dihydroartemisinin |
| Dihydroartemisinin is widely used as an intermediate in the preparation of other artemisinin-derived antimalarial drugs, recommended as the first-line anti-malarial drug with low toxicity. Dihydroartemisinin has anticancer activity, it inhibited cell proliferation via AKT/GSK3β/cyclinD1/ERK pathway and induced apoptosis is associated with inhibition of Sarco/Endoplasmic reticulum Calcium ATPase activity in colorectal cancer. | |
