Products with Antimalaric bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5047 | Podocarpusflavone A |
| 1. Podocarpusflavone A is the strongest noncytotoxic non-nucleotide molecule exhibiting a specific inhibitory activity against the RNA polymerase domain of DV-NS5 and thus is promising for chemotherapy development against dengue fever. 2. Podocarpusflavone A shows antimalarial activity in vitro against the chloroquine-sensitive F32 and chloroquine-resistant FcM29 strains of Plasmodium falciparum. | |
| BCN5052 | 2,6-Dimethoxy-1-acetonylquinol |
| 1. 2,6-Dimethoxy-1-acetonylquinol shows varying degrees of in vitro antimalarial activity against Plasmodium falciparum. 2. 2,6-Dimethoxy-1-acetonylquinol is devoid of significant cytotoxicity to the human oral epidermoid KB cancer cell line. | |
| BCN5187 | Heraclenin |
| 1. Heraclenin and imperatorin have an equally strong clastogenic effect . 2. Heraclenin can induce apoptosis in Jurkat leukemia cells. 3. Heraclenin has mutagenicity in Chlamydomonas reinhardii. 4. (+)-Heraclenin displays significant levels of antiplasmodial and moderate levels of antimicrobial activities. 5. Heraclenin has anticoagulant activity. 6. Heraclenin shows anti-inflammatory activity. | |
| BCN5255 | 8-Deoxygartanin |
| 1. 8-Deoxygartanin inhibits p65 activation with IC50 values of 11.3 microM. 2. 8-Deoxygartanin has cytotoxic effect on human melanoma cells, it is a potential candidate as anti-melanoma agents. 3. 8-Deoxygartanin is a butyrylcholinesterase (BChE) selective inhibitor. 4. 8-Deoxygartanin exhibits significant inhibition of self-induced β-amyloid (Aβ) aggregation, it has multifunctional activities against Alzheimer's disease (AD) and could be promising compounds for the therapy of AD. 5. 8-Deoxygartanin has antiplasmodial activity against the W2 strain of Plasmodium falciparum which is resistant to chloroquine and other antimalarial drugs. 6. 8-Deoxygartanin at 5 ug/ml can increase the cell cycle arrest in G(1) phase compared with untreated cells . | |
| BCN5280 | Nortrachelogenin |
| 1. (+)-Nortrachelogenin shows effects on the central nervous system producing depression in rabbits. 2. (-)-Nortrachelogenin can induce membrane disruption and caspase-dependent apoptosis. 3. Nortrachelogenin shows anti-plasmodium activity of 14.50 dg/ml. 4. Nortrachelogenin has anti-inflammatory properties. 5. Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth factor receptors, thereby efficiently synergizing with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), exposure. 6. (-)-Nortrachelogenin exerts its antibacterial effect by disorganizing and perturbing the cytoplasmic membrane. 7. (+)-Nortrachelogenin is moderately active against HIV-1 in vitro. 8. Nortrachelogenin shows moderate inhibiting activities on NF- κB signaling pathway induced by TNFα , with the IC50 value of 49.4 uM. | |
