Products with Antimalaric bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5293 | 9-Hydroxycalabaxanthone |
| 9-Hydroxycalabaxanthone exhibits cytotoxicity against the HT-29 cell line with ED50 values of 9.1 microM. The combination of 9-hydroxycalabaxanthone with α-mangostin shows the synergistic antimalarial interaction in both clones. | |
| BCN5371 | Pseudolycorine |
| 1. Pseudolycorine can halt HeLa cell growth at 10-1 mM or lower concentrations, it at its growth inhibitory concentrations blocks protein synthesis in ascites cells and stabilize HeLa cell polysomes in vivo. 2. Pseudolycorine exhibits cytotoxic profiles against cancer cell lines. 3. Pseudolycorine and haemanthamine show good activity in in vitro assays against Trypanosoma brucei rhodesiense, T. cruzi and Plasmodium falciparum with IC50 values in the range of 3.66 uM or lower. 4. Pseudolycorine, primarily studied as a new antiviral agent , it also shows remarkable antileukemic activity. | |
| BCN5393 | Cepharanthine |
| Cepharanthine has anti-plasmodial, anti-tumor , anti-inflammatory, antiallergic, antioxidant, and immunomodulatory activities in vivo, and it is a highly potent inhibitor of HIV-1 replication in a chronically infected monocytic cell line. Cepharanthine inhibits the HIV-1 entry process by reducing plasma membrane fluidity, and the plasma membrane is therefore an identical target to prevent viral infection. | |
| BCN5430 | Dehydroabietinol |
| 1. Dehydroabietinol inhibits growth of chloroquine-sensitive as well as chloroquine-resistant strains of Plasmodium falciparum cultivated in erythrocytes in vitro (IC 50 26-27 microM). | |
| BCN5463 | Lipiferolide |
| 1. Lipiferolide is an inhibitor of farnesyl protein transferase(FPTase), it inhibits the FPTase activity in a dose-dependent manner, and shows cell growth inhibitory activity against several tumor cells. 2. Liriodenine has antiplasmodial activity. 3. Lipiferolide and epitulipinolide diepoxide possess cytotoxic activity against KB cells. | |
