Products with Cytotoxic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN3171 | 3-oxo-Olean-12-en-28-oic acid |
| 3-oxo-Olean-12-en-28-oic acid and kulinone have cytotoxic effects, with IC50 values of 5.6-21.2 μg/mL. | |
| BCN3176 | Mahanine |
| 1. Mahanine has a dose- and time-dependent anti-proliferative activity in acute lymphoid (MOLT-3) and chronic myeloid (K562) leukemic cell lines. 2. Mahanine has effects on the activation of the apoptotic pathway in human leukemia U937 cells, causes the mitochondrial membranes to lose their permeability, resulting in caspase-3 activation and apoptosis. 3. Mahanine can reverse an epigenetically silenced gene, RASSF1A in prostate cancer cells by inhibiting DNMT activity that in turn down-regulates a key cell cycle regulator, cyclin D1, is an encouraging therapeutic choice for advanced prostatic cancer. 4. Mahanine inhibited growth of PC3 and LNCaP prostate cancer cells in a dose and time-dependent manner, inhibits growth and induces apoptosis in both androgen-responsive, LNCaP and androgen-independent, PC3 cells by targeting cell survival pathway. | |
| BCN3185 | Schisanlactone A |
| 1. Schisanlactone A shows cytotoxicity against KB (a human epidermal carcinoma) cells with the IC50 value of 63.3 uM. 2. Schisanlactone A is a dimerization inhibitor, with an IC50 value of 5.0 microg/mL. 3. Schisanlactone A shows appreciable inhibitory activity against HIV-1 protease with the IC50 value of 20 microM. | |
| BCN3190 | Norwogonin |
| Norwogonin(IC 50 = 1.1 microM) shows potent inhibitory activity toward VHR. | |
| BCN3193 | Bavachalcone |
| 1. Bavachalcone has antibiotic or anticancer activities. 2. Bavachalcone may be useful as a therapeutic drug for bone resorption-associated diseases. 3. Bavachalcone can protect the endothelial function by increasing AMPK activity and MnSOD expression and reducing mitochondrial oxidative stress. | |
