Products with Cytotoxic Bioactivity

Explore BioCrick products associated with Cytotoxic biological activity, including catalog numbers, product names and available bioactivity information.

Cat. No.	Product Name
BCN6743	Viroallosecurinine
1. Virosecurinine and viroallosecurinine were isolated as two cytotoxic alkaloids from the leaves of Securinega virosa. 2. Viroallosecurinine exhibits a MIC of 0.48 micrograms/ml for Pseudomonas aeruginosa and Staphylococcus aureus.
BCN6749	Vernolide B
1. Vernolide B has marginal cytoxicity (ED(50)=3.78, 5.88, 6.42 microg/ml for KB, NCI-661, and Hela, respectively).
BCN6755	Ustusolate C
1. Ustusolate C and ustusolate E exhibit moderate cytotoxicity against A549 and HL-60 cells with IC50 values of 10.5 and 9.0 microM, respectively.
BCN6756	Ustusolate A
1. Ustusolate A shows weak cytotoxicity against HL-60 and A549 cells with IC50 values of 20.6 and 30.0 microM, respectively.
BCN6774	Uncarinic acid E
1. Uncarinic acid E shows moderate cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and Bt549) (IC50 < 20.0 uM). 2. Uncarinic acid E induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resulting in cytochrome c release from the mitochondria. 3. Uncarinic acid E shows dose-dependent inhibitory activities against PLCgamma1 in vitro with the IC(50) value of 9.5-44.6 microM and inhibits the proliferation of human cancer cells with the IC(50) value of 0.5-6.5 microg/mL. 4. A mixture of uncarinic acid E and 27-O-p-(E)-coumaroyloxyursolic acid exhibits antiplasmodial activity, with the IC50 value of 2.9 microg/ml.

Cytotoxic Bioactivity Products