Products with Cytotoxic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5467 | Hirsutenone |
| 1. Hirsutenone exhibits anti-cancer effect against prostate cancer through a direct physical inhibition of Akt1/2. 2. Hirsutenone attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3-L1 preadipocytes, underscoring the potential therapeutic application of Hirsutenone in preventing obesity. 3. Hirsutenone may exert a preventive effect against microbial endotoxin lipopolysaccharide-induced inflammatory skin diseases through inhibition of ERK pathway-mediated NF-kappaB activation. 4. Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid peroxidation. 5. Hirsutenone shows potent cytotoxic activities against murine B16 melanoma cells and human SNU-C1 gastric cancer cells. 6. Hirustenone and hirsutanonol show promising anti-filarial activity both in vitro and in vivo studies. | |
| BCN5482 | Pashanone |
| 1. Pashanone possesses moderate antifungal activity. 2. Pashanone exhibits cytotoxic activity. | |
| BCN5507 | Pseudotaraxasterol |
| 1. Pseudotaraxasterol shows cytotoxic activity against MOLT-4 cells. | |
| BCN5513 | Hederagenin |
| Hederagenin shows anti-cancer,anti-inflammatory, antidepressant-like ,anticomplementary, and antimutagenic effects, it can evoke hemolysis on the erythrocytes, and has cytotoxic on various tumor cell lines, P-388, L-1210, U-937, HL-60, SNU-5 and HepG2. Hederagenin can inhibit LPS-stimulated expression of iNOS, COX-2, and NF-κB, regulate monoamine neurotransmitters and 5-HTT mRNA expression. | |
| BCN5528 | Betulin |
| Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC50 of 14.5 μM in K562 cell line. Betulin has hypoglycemic, antineoplastic, anti-HIV, antimalarial and anti-inflammatory activities. Betulin can improve hyperlipidemia and insulin resistance and reduce atherosclerotic plaques. Betulin inhibits pro-inflammatory cytokines expression and NF-κB signaling activation through STAT3 signaling, it is associated with activation of AMP kinase and inhibition of mTOR/p70S6K/pS6 signaling in these cells. | |
