Products with Cytotoxic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5306 | Cabraleahydroxylactone |
| 1. Cabraleahydroxylactone displays antimycobacterial activity against Mycobacterium tuberculosis, it is weakly cytotoxic to a breast cancer (BC) cell line. 2. Cabraleahydroxylactone shows antiviral activity against herpes simplex virus type-1 with an IC50 value of 3.20 ug/mL, in comparison with the standard acyclovir (IC50=1.90ug/mL). | |
| BCN5330 | (-)-Catechin gallate(CG) |
| (-)-Catechin gallate is a minor constituent in green tea catechins, it inhibits the activity of COX-1 and COX-2 enzymes. Catechin gallate (IC50=53 microM) shows cytotoxicity against the colorectal adenocarcinoma cell line HCT116, it also exhibits strong anti-proliferative and anti-inflammatory activities on pancreatic ductal adenocarcinoma (PDAC) cells. Catechin 3-gallate is a good inhibitor of maltase, with IC50 values of 62 uM, it inhibits both α-glucosidases and rabbit glycogen phosphorylase (GP) in vitro and in cell culture, would contribute to the protection or improvement of type 2 diabetes. | |
| BCN5343 | Cephalomannine |
| Cephalomannine is a taxol derivative with antitumor, antiproliferative properties, it shows cytotoxicity in human glial and neuroblastoma cell-lines. | |
| BCN5344 | Buddlejasaponin IV |
| 1. Buddlejasaponin IV has analgesic and anti-inflammatory effects, the inhibitions of the expressions of iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 by blocking NF-kappaB activation, are responsible for the anti-inflammatory effects of buddlejasaponin IV. 2. Buddlejasaponin IV can inhibit intrinsic and extrinsic hyperlipidemia and hypercholesterolemia in the rat. 3. Buddlejasaponin IV exerts antiinflammatory and cytotoxic effects against cancer cells,it can induce cell cycle arrest at G2/M phase and apoptosis in immortalized human oral keratinocytes. 4. Buddlejasaponin IV may possess antimetastatic potential by inducing anoikis and upregulating NAG-1 expression. | |
| BCN5360 | Gracillin |
| Gracillin has anti-tumor activity, can induce cell cycle arrest, oxidative stress, and apoptosis in HL60 cells, and has the potential to be developed as an antitumor agent. | |
