Products with Cytotoxic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5753 | Hedychenone |
| Hedychenone has anti-inflammatory activity, it also shows potent in vitro cytotoxic activity against cancerous cells. | |
| BCN5773 | Boehmenan |
| 1. Boehmenan exhibits cytotoxicity against both Wnt-dependent (HCT116) and Wnt-independent (RKO) cells, it decreases the expression of full, cytosolic and nuclear β-catenin along with c-myc in STF/293 cells, suggestes that boehmenan may have inhibited the Wnt signal by decreasing β-catenin levels. 2. (±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 um, it inhibits PTP1B activity in a competitive manner. 3. Boehmenan exhibits the potent cytotoxic effects against many cancer cell lines, boehmenan-mediated anti-tumor property is mediated by modulation of mitochondria and EGFR signaling pathway in A549 NSCLC cells. | |
| BCN5779 | Carpachromene |
| 1. Carpachromene blocks protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in LPS-stimulated macrophages, it could be a potential anti-inflammatory agent. 2. Carpachromene exhibits significant cytotoxicity against HepG2, PLC/PRF/5 and Raji cancer cell lines in vitro. 3. Carpachromene shows significant α-glucosidase inhibitory activity. | |
| BCN5784 | Norcepharadione B |
| Norcepharadione B shows good inhibitory activity against the replication of HSV-1, it also shows antimalarial activity with EC50 values of 7.5mug/ml. Norcepharadione B exhibits significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15) in vitro. Norcepharadione B shows significant inhibitory effects on both ADP-induced and thrombin-induced platelet aggregation. | |
| BCN5795 | Confluentin |
| 1. Confluentin has antimicrobial activity against the gram-positive bacteria. 2. Confluentin significantly inhibits compound 48/80-induced histamine release from rat peritoneal mast cells. 3. Confluentin shows weak cytotoxicity against four human tumor cell lines, HL-60, SMMC-7712, A-549, and MCF-7, in vitro. | |
