Products with Cytotoxic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5551 | Isorhamnetin |
| Isorhamnetin, a natural flavonol aglycon, is a tyrosinase inhibitor and has anti-adipogenic, cardioprotective, anti-tumor, and antioxidant activities. it inhibits the H(2)O(2)-induced activation of the intrinsic apoptotic pathway via ROS scavenging and ERK inactivation, it inhibits NF-κB signaling. Isorhamnetin prevents angiotensin II (AngII)-induced endothelial dysfunction by inhibiting the overexpression of p47(phox) and the subsequent increases O2-production, resulting in increased nitric oxide bioavailability. | |
| BCN5555 | Pinostrobin |
| Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aβ(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppressing the mitochondrial pathway of cellular apoptosis. Pinostrobin has anti-inflammatory, anti-hemorrhagic and analgesic activity, it can inhibit HSV-1 replication with 50% effective concentration (EC(50)) of 22.71 ± 1.72 ug/ml. | |
| BCN5588 | Bergaptol |
| Bergaptol acts as a potent inhibitor of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM.Bergaptol shows very good radical scavenging activity, it induces dose-dependent cytotoxic effect on MCF-7 cell viability. | |
| BCN5624 | Taiwanhomoflavone B |
| 1. Taiwanhomoflavone B is cytotoxic with ED(50) values of 3.8 and 3.5 microg/ml, against KB oral epidermoid carcinoma and Hepa-3B hepatoma cells, respectively. | |
| BCN5640 | Cerevisterol |
| 1. Cerevisterol is a cytotoxic steroid, can inhibit the activity of DNA polymerase alpha. 2. Cerevisterol can stimulate NGF-mediated neurite outgrowth on PC12 cells. | |
