BergaptolCAS# 486-60-2 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 486-60-2 | SDF | Download SDF |
| PubChem ID | 5280371 | Appearance | Yellow powder |
| Formula | C11H6O4 | M.Wt | 202.2 |
| Type of Compound | Coumarins | Storage | Desiccate at -20°C |
| Solubility | DMSO : ≥ 50 mg/mL (247.33 mM) H2O : < 0.1 mg/mL (insoluble) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | 4-hydroxyfuro[3,2-g]chromen-7-one | ||
| SMILES | C1=CC(=O)OC2=CC3=C(C=CO3)C(=C21)O | ||
| Standard InChIKey | GIJHDGJRTUSBJR-UHFFFAOYSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Bergaptol acts as a potent inhibitor of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM.Bergaptol shows very good radical scavenging activity, it induces dose-dependent cytotoxic effect on MCF-7 cell viability. |
| Targets | CYP3A4 |
| In vitro | Antitumor and apoptotic effects of bergaptol are mediated via mitochondrial death pathway and cell cycle arrest in human breast carcinoma cells.[Reference: WebLink]Bangl. J. Pharmacol., 2016, 11(2):489.The aim of the present research work was to investigate the anti-cancer and apoptotic effects of Bergaptol in human breast cancer cells (MCF-7). |
| Kinase Assay | Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit.[Pubmed: 17400460]Bioorg Med Chem. 2007 Jun 1;15(11):3684-91.Grapefruit juice has been shown to increase the oral bioavailability of several clinically important drugs by inhibiting first pass metabolism. Several compounds in grapefruit juice have shown different biological activities. Unique among them are furocoumarins with potent inhibitory activity against cytochrome P450 enzymes. |
Bergaptol Dilution Calculator
Bergaptol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.9456 mL | 24.728 mL | 49.456 mL | 98.912 mL | 123.64 mL |
| 5 mM | 0.9891 mL | 4.9456 mL | 9.8912 mL | 19.7824 mL | 24.728 mL |
| 10 mM | 0.4946 mL | 2.4728 mL | 4.9456 mL | 9.8912 mL | 12.364 mL |
| 50 mM | 0.0989 mL | 0.4946 mL | 0.9891 mL | 1.9782 mL | 2.4728 mL |
| 100 mM | 0.0495 mL | 0.2473 mL | 0.4946 mL | 0.9891 mL | 1.2364 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- (-)-Cotinine
Catalog No.:BCC7569
CAS No.:486-56-6
- (S)-Coclaurine
Catalog No.:BCN5585
CAS No.:486-39-5
- Daphnetin
Catalog No.:BCN1051
CAS No.:486-35-1
- Fraxinol
Catalog No.:BCN5584
CAS No.:486-28-2
- Isofraxidin
Catalog No.:BCN2327
CAS No.:486-21-5
- PMX 464
Catalog No.:BCC6348
CAS No.:485842-97-5
- Mirabijalone D
Catalog No.:BCN4071
CAS No.:485811-84-5
- Choline sulphate
Catalog No.:BCN1792
CAS No.:4858-96-2
- Proanthocyanidins
Catalog No.:BCN6313
CAS No.:4852-22-6
- 5,7,3'-Trihydroxyflavanone
Catalog No.:BCC8269
CAS No.:104732-07-2
- Hydrangetin
Catalog No.:BCN7439
CAS No.:485-90-5
- Formononetin
Catalog No.:BCN1061
CAS No.:485-72-3
- Ononin
Catalog No.:BCN5926
CAS No.:486-62-4
- Isoformononetin
Catalog No.:BCN8206
CAS No.:486-63-5
- Vasicinone
Catalog No.:BCN5589
CAS No.:486-64-6
- Daidzein
Catalog No.:BCN5590
CAS No.:486-66-8
- Harman
Catalog No.:BCN3998
CAS No.:486-84-0
- N-Methylcytisine
Catalog No.:BCN1266
CAS No.:486-86-2
- alpha-Isolupanine
Catalog No.:BCN7989
CAS No.:486-87-3
- Anagyrine
Catalog No.:BCN3049
CAS No.:486-89-5
- Thermopsine
Catalog No.:BCN2603
CAS No.:486-90-8
- AZD2858
Catalog No.:BCC4509
CAS No.:486424-20-8
- CIQ
Catalog No.:BCC7862
CAS No.:486427-17-2
- O-Acetylcyclocalopin A
Catalog No.:BCN5586
CAS No.:486430-93-7
Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit.[Pubmed:17400460]
Bioorg Med Chem. 2007 Jun 1;15(11):3684-91.
Grapefruit juice has been shown to increase the oral bioavailability of several clinically important drugs by inhibiting first pass metabolism. Several compounds in grapefruit juice have shown different biological activities. Unique among them are furocoumarins with potent inhibitory activity against cytochrome P450 enzymes. In the present study, two bioactive compounds were isolated from grapefruit juice and grapefruit peel oil. The purity of the isolated compounds has been analyzed by HPLC. Structures of the compounds were elucidated by extensive NMR and mass spectral studies and identified as Bergaptol and geranylcoumarin. The isolated compounds were tested for their radical scavenging activity using 2,2'-azobis (3-ethylbenz-thiazoline-6-sulfonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazil (DPPH) methods at different concentrations. Bergaptol showed very good radical scavenging activity at all the tested concentrations. Furthermore, these compounds were evaluated for their inhibitory activity against CYP3A4 enzyme. Bergaptol and geranylcoumarin were found to be potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC(50) value of 24.92 and 42.93 microM, respectively.
