Mirabijalone D

CAS# 485811-84-5

Mirabijalone D

Catalog No. BCN4071----Order now to get a substantial discount!

Product Name & Size Price Stock
Mirabijalone D: 5mg $960 In Stock
Mirabijalone D: 10mg Please Inquire In Stock
Mirabijalone D: 20mg Please Inquire Please Inquire
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Quality Control of Mirabijalone D

Number of papers citing our products

Chemical structure

Mirabijalone D

3D structure

Chemical Properties of Mirabijalone D

Cas No. 485811-84-5 SDF Download SDF
PubChem ID 11013288 Appearance Powder
Formula C18H14O7 M.Wt 342.3
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 3,6,11-trihydroxy-9-methoxy-10-methyl-6H-chromeno[3,4-b]chromen-12-one
SMILES CC1=C(C=C2C(=C1O)C(=O)C3=C(O2)C(OC4=C3C=CC(=C4)O)O)OC
Standard InChIKey SUWMBRRWYKHHDH-UHFFFAOYSA-N
Standard InChI InChI=1S/C18H14O7/c1-7-10(23-2)6-12-14(15(7)20)16(21)13-9-4-3-8(19)5-11(9)25-18(22)17(13)24-12/h3-6,18-20,22H,1-2H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Mirabijalone D

The herbs of Mirabilis jalapa

Biological Activity of Mirabijalone D

Description1. Mirabijalone D is a non-competitive inhibitor based on the Dixon plot. 2. Mirabijalone D inhibits Aβ1–42 production by 43.7% in APPSW-N2a cells.
TargetsBeta Amyloid

Mirabijalone D Dilution Calculator

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Mirabijalone D Molarity Calculator

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Preparing Stock Solutions of Mirabijalone D

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9214 mL 14.6071 mL 29.2141 mL 58.4283 mL 73.0353 mL
5 mM 0.5843 mL 2.9214 mL 5.8428 mL 11.6857 mL 14.6071 mL
10 mM 0.2921 mL 1.4607 mL 2.9214 mL 5.8428 mL 7.3035 mL
50 mM 0.0584 mL 0.2921 mL 0.5843 mL 1.1686 mL 1.4607 mL
100 mM 0.0292 mL 0.1461 mL 0.2921 mL 0.5843 mL 0.7304 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Mirabijalone D

beta-Secretase (BACE1)-inhibiting C-methylrotenoids from Abronia nana suspension cultures.[Pubmed:24835197]

Bioorg Med Chem Lett. 2014 Jul 1;24(13):2945-8.

Suspension cultures of Abronia nana were established to produce C-methylisoflavones. A new C-methylrotenoid, named abronione A (2), was isolated along with three known rotenoids, boeravinone D (1), boeravinone A methyl ether (3), and Mirabijalone D (4). The IC50 values of compounds 1, 2, and 4 on beta-secretase (BACE1) were 4.77, 62.21, and 4.24 muM, respectively, whereas 3 was inactive. At concentrations up to 1.0 mM, the compounds did not inhibit other proteases such as trypsin, chymotrypsin, and elastase, indicating that they were specific inhibitors of beta-secretase. Compounds 1 and 4 were non-competitive inhibitors based on the Dixon plot and with Ki values of 5.01 and 4.28 muM, respectively. At 50 muM, compound 4 inhibited Abeta1-42 production by 43.7% in APPSW-N2a cells.

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