Mirabijalone DCAS# 485811-84-5 |
Quality Control & MSDS
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| Cas No. | 485811-84-5 | SDF | Download SDF |
| PubChem ID | 11013288 | Appearance | Powder |
| Formula | C18H14O7 | M.Wt | 342.3 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 3,6,11-trihydroxy-9-methoxy-10-methyl-6H-chromeno[3,4-b]chromen-12-one | ||
| SMILES | CC1=C(C=C2C(=C1O)C(=O)C3=C(O2)C(OC4=C3C=CC(=C4)O)O)OC | ||
| Standard InChIKey | SUWMBRRWYKHHDH-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C18H14O7/c1-7-10(23-2)6-12-14(15(7)20)16(21)13-9-4-3-8(19)5-11(9)25-18(22)17(13)24-12/h3-6,18-20,22H,1-2H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Mirabilis jalapa
| Description | 1. Mirabijalone D is a non-competitive inhibitor based on the Dixon plot. 2. Mirabijalone D inhibits Aβ1–42 production by 43.7% in APPSW-N2a cells. |
| Targets | Beta Amyloid |
Mirabijalone D Dilution Calculator
Mirabijalone D Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.9214 mL | 14.6071 mL | 29.2141 mL | 58.4283 mL | 73.0353 mL |
| 5 mM | 0.5843 mL | 2.9214 mL | 5.8428 mL | 11.6857 mL | 14.6071 mL |
| 10 mM | 0.2921 mL | 1.4607 mL | 2.9214 mL | 5.8428 mL | 7.3035 mL |
| 50 mM | 0.0584 mL | 0.2921 mL | 0.5843 mL | 1.1686 mL | 1.4607 mL |
| 100 mM | 0.0292 mL | 0.1461 mL | 0.2921 mL | 0.5843 mL | 0.7304 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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beta-Secretase (BACE1)-inhibiting C-methylrotenoids from Abronia nana suspension cultures.[Pubmed:24835197]
Bioorg Med Chem Lett. 2014 Jul 1;24(13):2945-8.
Suspension cultures of Abronia nana were established to produce C-methylisoflavones. A new C-methylrotenoid, named abronione A (2), was isolated along with three known rotenoids, boeravinone D (1), boeravinone A methyl ether (3), and Mirabijalone D (4). The IC50 values of compounds 1, 2, and 4 on beta-secretase (BACE1) were 4.77, 62.21, and 4.24 muM, respectively, whereas 3 was inactive. At concentrations up to 1.0 mM, the compounds did not inhibit other proteases such as trypsin, chymotrypsin, and elastase, indicating that they were specific inhibitors of beta-secretase. Compounds 1 and 4 were non-competitive inhibitors based on the Dixon plot and with Ki values of 5.01 and 4.28 muM, respectively. At 50 muM, compound 4 inhibited Abeta1-42 production by 43.7% in APPSW-N2a cells.
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