Harman

MAO-A and MAO-B inhibitor CAS# 486-84-0

Harman

Catalog No. BCN3998----Order now to get a substantial discount!

Product Name & Size Price Stock
Harman: 5mg Please Inquire In Stock
Harman: 10mg Please Inquire In Stock
Harman: 20mg Please Inquire Please Inquire
Harman: 50mg Please Inquire Please Inquire
Harman: 100mg Please Inquire Please Inquire
Harman: 200mg Please Inquire Please Inquire
Harman: 500mg Please Inquire Please Inquire
Harman: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of Harman

Number of papers citing our products

Chemical structure

Harman

3D structure

Chemical Properties of Harman

Cas No. 486-84-0 SDF Download SDF
PubChem ID 5281404 Appearance Powder
Formula C12H10N2 M.Wt 182.2
Type of Compound Alkaloids Storage Desiccate at -20°C
Synonyms Harman
Solubility Soluble to 10 mM in 1eq. HCl
Chemical Name 1-methyl-9H-pyrido[3,4-b]indole
SMILES CC1=NC=CC2=C1NC3=CC=CC=C23
Standard InChIKey PSFDQSOCUJVVGF-UHFFFAOYSA-N
Standard InChI InChI=1S/C12H10N2/c1-8-12-10(6-7-13-8)9-4-2-3-5-11(9)14-12/h2-7,14H,1H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Harman

The herbs of Rauvolfia verticillata

Biological Activity of Harman

Description1. Harman exhibits neuroactive activity in the human body.

Harman Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Harman Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Harman

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.4885 mL 27.4424 mL 54.8847 mL 109.7695 mL 137.2119 mL
5 mM 1.0977 mL 5.4885 mL 10.9769 mL 21.9539 mL 27.4424 mL
10 mM 0.5488 mL 2.7442 mL 5.4885 mL 10.9769 mL 13.7212 mL
50 mM 0.1098 mL 0.5488 mL 1.0977 mL 2.1954 mL 2.7442 mL
100 mM 0.0549 mL 0.2744 mL 0.5488 mL 1.0977 mL 1.3721 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Harman

Bioactive beta-carbolines norharman and harman in traditional and novel raw materials for chicory coffee.[Pubmed:25577081]

Food Chem. 2015 May 15;175:280-3.

The beta-carboline compounds norHarman and Harman exhibit neuroactive activity in the human body. Chicory coffee has proved to be a source of beta-carboline compounds. This study assessed the norHarman and Harman contents of traditional and novel raw materials for the production of chicory coffee, as well as in samples of chicory coffee with novel additives. The highest content of the beta-carbolines among the traditional raw materials was recorded in roasted sugar beet (2.26 mug/g), while roasting the chicory caused a 25-fold increase in the content of norHarman in this raw material (from 0.05 to 1.25 mug/g). In novel raw materials not subjected to the action of high temperature, beta-carboline was not detected. Among the roasted novel raw materials, the highest contents of Harman and norHarman were found in artichokes. High Harman levels were also recorded in roasted chokeberry.

Harmane produces hypotension following microinjection into the RVLM: possible role of I(1)-imidazoline receptors.[Pubmed:10725251]

Br J Pharmacol. 2000 Mar;129(6):1057-9.

The beta-carboline, Harmane (0.1 - 1.0 nmol) produces dose dependent hypotension when microinjected unilaterally into the rostral ventrolateral medulla (RVLM) of the anaesthetized rat. The potency of Harmane on blood pressure is similar to that of the imidazoline, clonidine. The hypotensive effects of both clonidine and Harmane are reversed by microinjection of the relatively I(1)-receptor selective antagonist efaroxan (20 nmol). These results are consistent with Harmane acting at an I(1)-receptor in the RVLM. This is the first report of an endogenous ligand for I(1)-receptors that has central effects on blood pressure.

The I1-imidazoline receptor and its cellular signaling pathways.[Pubmed:10415895]

Ann N Y Acad Sci. 1999 Jun 21;881:35-53.

Two primary questions are addressed. First, do I1-imidazoline binding sites fulfill all the essential criteria for identification as a true receptor? Second, what are the cellular signaling pathways coupled to this novel receptor? I1-imidazoline binding sites show specificity in binding assays, linkage to physiologic functions, appropriate anatomic, and cellular and subcellular localization. Most important, binding affinities correlate with functional drug responses. I1-imidazoline binding sites meet several additional criteria identified with functional receptors: they show physiologic regulation and endogenous ligands and, most crucially, are coupled to cellular signaling events. A series of studies have identified cellular events triggered by I1-imidazoline receptor occupancy. This receptor is not coupled to conventional pathways downstream of heterotrimeric G-proteins, such as activation or inhibition of adenylyl or guanylyl cyclases, stimulation of inositol phospholipid hydrolysis, or induction of rapid calcium fluxes. The I1-imidazoline receptor is coupled to choline phospholipid hydrolysis, leading to the generation of diacylglyceride, arachidonic acid, and eicosanoids. Additional cellular responses include inhibition of Na+/H+ exchange and induction of genes for catecholamine synthetic enzymes. The signaling pathways linked to the I1-imidazoline receptor are similar to those of the interleukin family, implying that I1-receptors may belong to the family of neurocytokine receptors.

beta-Carbolines as selective monoamine oxidase inhibitors: in vivo implications.[Pubmed:7130973]

J Neural Transm. 1982;54(3-4):209-18.

The inhibitory action of a range of beta-carbolines on human and rat monoamine oxidase (MAO) A and B has been studied. Concentrations of 5-hydroxytryptamine and phenylethylamine, approximately at their Km values, were used as substrates for MAO A and B respectively. A wide variation in selectivity was found, with harmaline being 10,000 times more potent an inhibitor of A than B whereas, using tetrahydro-beta-carboline and Harmane, the difference was nearer to ten-fold. Of the carbolines which have been found endogenously, tetrahydro-beta-carboline, 6-methoxytetrahydro-beta-carboline and Harmane are all sufficiently potent inhibitors of human MAO A, with I50 values of 5 X 10(-6), 10(-6), 5 X 10(-7) M respectively, for this property to be of possible physiological significance. Harmane, with an I50 of 5 X 10(-6) M, might also play a role as an inhibitor of MAO B.

Keywords:

Harman,486-84-0,Harman,Natural Products,General Imidazolines, buy Harman , Harman supplier , purchase Harman , Harman cost , Harman manufacturer , order Harman , high purity Harman

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: