ThermopsineCAS# 486-90-8 |
- Anagyrine
Catalog No.:BCN3049
CAS No.:486-89-5
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| Cas No. | 486-90-8 | SDF | Download SDF |
| PubChem ID | 638234 | Appearance | Cryst. |
| Formula | C15H20N2O | M.Wt | 244.33 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Synonyms | (-)-Thermopsine | ||
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (1R,9R,10S)-7,15-diazatetracyclo[7.7.1.02,7.010,15]heptadeca-2,4-dien-6-one | ||
| SMILES | C1CCN2CC3CC(C2C1)CN4C3=CC=CC4=O | ||
| Standard InChIKey | FQEQMASDZFXSJI-UPJWGTAASA-N | ||
| Standard InChI | InChI=1S/C15H20N2O/c18-15-6-3-5-14-11-8-12(10-17(14)15)13-4-1-2-7-16(13)9-11/h3,5-6,11-13H,1-2,4,7-10H2/t11-,12-,13+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Thermopsine exhibits antibacterial activity. |
| Targets | Antifection |
| In vitro | Myopathy in cattle induced by alkaloid extracts from Thermopsis montanta, Laburnum anagyroides and a Lupinus sp.[Pubmed: 2246392]J Comp Pathol. 1990 Aug;103(2):169-82.
Quinolizidine alkaloids from Sophora velutina subsp. zimbabweensis (Fabaceae: Sophoreae).[Pubmed: 22978215]Nat Prod Commun. 2012 Aug;7(8):999-1003.
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Thermopsine Dilution Calculator
Thermopsine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.0928 mL | 20.4641 mL | 40.9283 mL | 81.8565 mL | 102.3206 mL |
| 5 mM | 0.8186 mL | 4.0928 mL | 8.1857 mL | 16.3713 mL | 20.4641 mL |
| 10 mM | 0.4093 mL | 2.0464 mL | 4.0928 mL | 8.1857 mL | 10.2321 mL |
| 50 mM | 0.0819 mL | 0.4093 mL | 0.8186 mL | 1.6371 mL | 2.0464 mL |
| 100 mM | 0.0409 mL | 0.2046 mL | 0.4093 mL | 0.8186 mL | 1.0232 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Quinolizidine alkaloids from Sophora velutina subsp. zimbabweensis (Fabaceae: Sophoreae).[Pubmed:22978215]
Nat Prod Commun. 2012 Aug;7(8):999-1003.
Three novel quinolizidine alkaloids, N-methylenehydroxycytisine (1), 6,7-dihydroxylupanine (2), and velutinine (3) have been isolated from the fruits and pods (1 and 2) and stem bark (3) of Sophora velutina subsp. zimbabweensis along with the known quinolizidine alkaloids, 7-hydroxylupanine (4), Thermopsine (5), N-methylcytisine (6), cytisine (7), an aromatic ester, methyl-3-(3',4'-dimethoxyphenyl)-2-propenoate (8) and the triterpenoids, lup-20(29)-ene-3beta-ol (9) and 12-oleanen-3-one (10). Compounds 6 and 10 showed good antibacterial activity against E. faecalis, with MIC values of 20.8 and 10.9 microg mL(-1), respectively. The other compounds tested exhibited low to moderate antibacterial activity.
Myopathy in cattle induced by alkaloid extracts from Thermopsis montanta, Laburnum anagyroides and a Lupinus sp.[Pubmed:2246392]
J Comp Pathol. 1990 Aug;103(2):169-82.
A purified alkaloid preparation containing N-methylcytisine, cytisine, 5,6-dehydrolupanine, Thermopsine and anagyrine from Thermopsis montana induced prolonged recumbency and microscopic acute hyaline skeletal myodegeneration with myofibre regeneration in cattle similar in type and severity to that induced by Thermopsis montanta plant material. This indicates that the alkaloid(s) of Thermopsis montana are responsible for the myopathy caused by the plant. An alkaloid preparation containing mostly anagyrine from a Lupinus sp. and an alkaloid preparation containing only cytisine from Laburnum anagyroides each caused microscopic skeletal muscle degeneration and necrosis similar to, but less severe than, the alkaloid extract from T. montana, but without clinical recumbency. Dosage and severity of response suggest that neither of those two alkaloids alone can account for the effects induced by Thermopsis. The data suggest that quinolizidine alkaloids with a alpha-pyridone A-ring may be responsible for the lesions and that individual alpha-pyridones may have additive effects.
