Products with Cytotoxic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5170 | Erysotrine |
| 1. Erysotrine does not show cytotoxic activity by itself, but exhibits significant cytotoxicity when combines with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). 2. (+)-Erysotrine shows potent dosedependant antifeedant activity at concentrations ≥100 ppm. | |
| BCN5172 | Ervamycine |
| 1. 11-Methoxytabersonine(Ervamycine) exhibits inhibitory effects against five human cancer cell lines , with IC(50) values comparable to those of cisplatin and vinorelbine. | |
| BCN5176 | Dihydrodehydrodiconiferyl alcohol |
| 1. Dihydrodehydrodiconiferyl alcohol may be useful candidates for developing therapeutic agents for the prevention and treatment of hepatic fibrosis. 2. Dihydrodehydrodiconiferyl alcohol exhibits in vitro cytotoxicity in various cancer cell lines. | |
| BCN5178 | Reynosin |
| 1. Reynosin has hepatoprotective effects, it can inhibit thioacetamide-induced apoptosis in primary hepatocytes and an in vivo mouse model. 2. Reynosin has protective effect against dopamine-induced neuronal cell death, which may be due to the reciprocal up-regulation of E6-associated protein and down-regulation of α-synuclein protein expression. 3. Reynosin exhibits a dose-dependent inhibition on CINC-1 induction in LPS-stimulated NRK-52E cells, where 50% of inhibitory effect was shown at the concentration of about 1 microM. 4. Reynosin has strong anti-mycobactericidal activity, with a minimal bactericidal concentration (MBC) of 128ug/mL against the H37Rv, 366-2009 and 104-2010 Mtb strains and a minimal inhibitory concentration (MIC) of 64, 64, 128, 128 and 128ug/mL against the H37Rv, 104-2010, 63-2009, 366-2009 and 430-2010 Mtb strains, respectively. 5. Reynosin can inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophages. 6. Reynosin shows cytotoxicity against the KB cancer cell line (ATCC CCL17), with IC50 value of 2.7 microg/mL. 7. Reynosin shows moderate anti-inflammatory activity, it exhibits a concentration-related decrease in the levels of IL-1β, IL-6, TNF-α, PGE2, lipoxgenase-5, and COX-2. | |
| BCN5181 | 7-Geranyloxy-6-methoxycoumarin |
| 1. 7-Geranyloxy-6-methoxycoumarin shows significant cytotoxicity against three cell lines (A549, SMMC-7721 and BALL-1). | |
