PseudotaraxasterolCAS# 464-98-2 |
2D Structure
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
Cas No. | 464-98-2 | SDF | Download SDF |
PubChem ID | 3034659 | Appearance | Powder |
Formula | C30H50O | M.Wt | 426.7 |
Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | (3S,6aR,6aR,6bR,8aS,12S,12aR,14aR,14bR)-4,4,6a,6b,8a,11,12,14b-octamethyl-2,3,4a,5,6,6a,7,8,9,12,12a,13,14,14a-tetradecahydro-1H-picen-3-ol | ||
SMILES | CC1C2C3CCC4C5(CCC(C(C5CCC4(C3(CCC2(CC=C1C)C)C)C)(C)C)O)C | ||
Standard InChIKey | NGFFRJBGMSPDMS-MHFMPXFTSA-N | ||
Standard InChI | InChI=1S/C30H50O/c1-19-11-14-27(5)17-18-29(7)21(25(27)20(19)2)9-10-23-28(6)15-13-24(31)26(3,4)22(28)12-16-30(23,29)8/h11,20-25,31H,9-10,12-18H2,1-8H3/t20-,21-,22?,23-,24+,25-,27-,28+,29-,30-/m1/s1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | 1. Pseudotaraxasterol shows cytotoxic activity against MOLT-4 cells. |
Targets | AChR |
Pseudotaraxasterol Dilution Calculator
Pseudotaraxasterol Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 2.3436 mL | 11.7178 mL | 23.4357 mL | 46.8713 mL | 58.5892 mL |
5 mM | 0.4687 mL | 2.3436 mL | 4.6871 mL | 9.3743 mL | 11.7178 mL |
10 mM | 0.2344 mL | 1.1718 mL | 2.3436 mL | 4.6871 mL | 5.8589 mL |
50 mM | 0.0469 mL | 0.2344 mL | 0.4687 mL | 0.9374 mL | 1.1718 mL |
100 mM | 0.0234 mL | 0.1172 mL | 0.2344 mL | 0.4687 mL | 0.5859 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Asiatic acid
Catalog No.:BCN5506
CAS No.:464-92-6
- Conquinamine
Catalog No.:BCN6622
CAS No.:464-86-8
- Quinamine
Catalog No.:BCN6590
CAS No.:464-85-7
- Arenobufagin
Catalog No.:BCN5401
CAS No.:464-74-4
- Benzopinacol
Catalog No.:BCC8860
CAS No.:464-72-2
- (+)-Camphor
Catalog No.:BCN7161
CAS No.:464-49-3
- (-)-Camphor
Catalog No.:BCN7160
CAS No.:464-48-2
- (-)-Borneol
Catalog No.:BCC8897
CAS No.:464-45-9
- (+)-Borneol
Catalog No.:BCC8376
CAS No.:464-43-7
- Bay 55-9837
Catalog No.:BCC5932
CAS No.:463930-25-8
- alpha-Linolenic acid
Catalog No.:BCN8319
CAS No.:463-40-1
- Gnemonol B
Catalog No.:BCN3399
CAS No.:462636-74-4
- Arjunolic acid
Catalog No.:BCN5508
CAS No.:465-00-9
- Germanicol
Catalog No.:BCN7507
CAS No.:465-02-1
- Gamabufotalin
Catalog No.:BCN2358
CAS No.:465-11-2
- Neritaloside
Catalog No.:BCN5509
CAS No.:465-13-4
- Oleandrin
Catalog No.:BCN5511
CAS No.:465-16-7
- Polyporenic acid C
Catalog No.:BCN3645
CAS No.:465-18-9
- Bufalin
Catalog No.:BCN1046
CAS No.:465-21-4
- Resibufogenin
Catalog No.:BCN5366
CAS No.:465-39-4
- Quinovic acid
Catalog No.:BCN5512
CAS No.:465-74-7
- Marrubiin
Catalog No.:BCC8208
CAS No.:465-92-9
- Hederagenin
Catalog No.:BCN5513
CAS No.:465-99-6
- alpha-Spinasterol acetate
Catalog No.:BCN5510
CAS No.:4651-46-1
[Chemical constituents of Eupatorium lindleyanum].[Pubmed:22792793]
Zhongguo Zhong Yao Za Zhi. 2012 Apr;37(7):937-40.
To study chemical constituents of Eupatorium lindleyanum. Ethyl acetate extractive fractions were separated with silica gel and Sephadex LH-20 by column chromatography, and their structures were identified on the basis of spectroscopic analysis and chemical evidence. Sixteen compounds were separated and identified as scopoletin (1), 6, 7-dimethylesculetin (2), nepetin (3), eupatrin (4), luteolin (5), isoquerecitrin (6), jaceosidin (7), quceritin (8), kaempferol (9), rutin (10), cirsiliol (11), taraxasterylacetate (12), pseudotaraxasteryl acetate (13), Pseudotaraxasterol (14), butanoic acid (15) and n-hexadecanoic acid (16). Of them, compounds 1-6 and 11, 13 and 15 were separated from this plant for the first time.
Cytotoxic activity and chemical constituents of Anthemis mirheydari.[Pubmed:26864903]
Pharm Biol. 2016 Oct;54(10):2044-9.
Context The genus Anthemis L. (Asteraceae) comprises about 195 species which are widely used in the pharmaceutical, cosmetic and food industries. Objective Anthemis mirheydari Iranshar, an endemic plant from Iran, was investigated for its cytotoxic properties and chemical constituents. Materials and methods The whole parts of the plant (320 g) were extracted by dichloromethane and methanol for four days, successively. The cytotoxic activity of both dichloromethane and methanol extracts were assayed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide colorimetric methods against three human cancer cell lines including LS180, MCF-7 and MOLT-4. Different concentrations (10-100 mug/mL) of the plant extracts were tested to obtain IC50 values. The dichloromethane extract of A. mirheydari was subjected to silica gel-column and thin layer chromatography for purification of its chemical constituents and the isolated compounds were further tested against MOLT-4 cells. The structures of the pure compounds were elucidated using different spectral data including nuclear magnetic resonance and electron impact mass spectra. Results The IC50 values of the dichloromethane extract were 30.8 +/- 6.7, 25.2 +/- 6.5 and 8.6 +/- 1.1 mug/mL (means +/- standard error) for the above-mentioned cell lines, respectively. Two triterpenoids, taraxasterol (1) and Pseudotaraxasterol (2), one sterol, beta-sitosterol (3) and one coumarin, 7-methoxycoumarin (4) were isolated from the extract. The IC50 of the mixture of compounds 1 and 2 as well as compounds 3 and 4 were higher (>100 muM) than that reported for the dichloromethane extract against MOLT-4 cells. Conclusion The dichloromethane extract was the most active one among the tested material.
Triterpenoids with acetylcholinesterase inhibition from Chuquiraga erinacea D. Don. subsp. erinacea (Asteraceae).[Pubmed:19918718]
Planta Med. 2010 Apr;76(6):607-10.
A bioactivity-guided approach was taken to identify the acetylcholinesterase (AChE) inhibitory agents in the ethanolic extract of Chuquiraga erinacea D. Don. subsp. erinacea leaves using a bioautographic method. This permitted the isolation of the pentacyclic triterpenes calenduladiol (1), faradiol (2), heliantriol B2 (3), lupeol (4), and a mixture of alpha-and beta-amyrin ( 5A and 5B) as active constituents. Pseudotaraxasterol (6) and taraxasterol (7) were also isolated from this extract and showed no activity at the same analytical conditions. Compound 1 showed the highest AChE inhibitory activity with 31.2 % of inhibition at 0.5 mM. Looking forward to improve the water solubility of the active compounds, the sodium sulfate ester of 1 was prepared by reaction with the (CH3)3N.SO3 complex. The semisynthetic derivative disodium calenduladiol disulfate (8) elicited higher AChE inhibition than 1 with 94.1 % of inhibition at 0.5 mM (IC (50) = 0.190 +/- 0.003 mM). Compounds 1, 2, 3, 5, 6, and 7 are reported here for the first time in C. erinacea. This is the first report of AChE inhibition from calenduladiol (1) as well as from a sulfate derived from a natural product.