(+)-BorneolCAS# 464-43-7 |
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Quality Control & MSDS
3D structure
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| Cas No. | 464-43-7 | SDF | Download SDF |
| PubChem ID | 6552009 | Appearance | Powder |
| Formula | C10H18O | M.Wt | 154 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : ≥ 100 mg/mL (648.30 mM) H2O : < 0.1 mg/mL (insoluble) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | (1R,3S,4R)-4,7,7-trimethylbicyclo[2.2.1]heptan-3-ol | ||
| SMILES | CC1(C2CCC1(C(C2)O)C)C | ||
| Standard InChIKey | DTGKSKDOIYIVQL-WEDXCCLWSA-N | ||
| Standard InChI | InChI=1S/C10H18O/c1-9(2)7-4-5-10(9,3)8(11)6-7/h7-8,11H,4-6H2,1-3H3/t7-,8+,10+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
(+)-Borneol Dilution Calculator
(+)-Borneol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 6.4935 mL | 32.4675 mL | 64.9351 mL | 129.8701 mL | 162.3377 mL |
| 5 mM | 1.2987 mL | 6.4935 mL | 12.987 mL | 25.974 mL | 32.4675 mL |
| 10 mM | 0.6494 mL | 3.2468 mL | 6.4935 mL | 12.987 mL | 16.2338 mL |
| 50 mM | 0.1299 mL | 0.6494 mL | 1.2987 mL | 2.5974 mL | 3.2468 mL |
| 100 mM | 0.0649 mL | 0.3247 mL | 0.6494 mL | 1.2987 mL | 1.6234 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Development and validation an LC-MS/MS method to quantify (+)-borneol in rat plasma: Application to a pharmacokinetic study.[Pubmed:30743141]
J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Mar 1;1109:121-127.
(+)-Borneol, a bicyclic monoterpene, has been shown to possess valuable biological properties and potential as a pharmaceutical agent due to anti-inflammatory, anti-oxidant and GABA receptor-enhancing functions; it also enhances the permeability of the blood brain barrier to improve the efficacy of CNS drugs. In this study, we have developed a simple, selective, and rapid liquid chromatography-tandem mass spectrometry method for the assay of (+)-Borneol in rat plasma. Verapamil was used as an internal standard. Plasma samples were deproteinized using methanol. The analyte was detected by a mass spectrometer with positive atmospheric pressure chemical ionization by multiple reaction monitoring mode for transitions at m/z [M+H](+) 137.2-->81.0 for (+)-Borneol and 455.2-->165.1 for verapamil. The method has been fully validated to ensure good selectivity, a satisfactory lower limit of quantification at 10.0ng/mL, acceptable intra- and inter-day accuracy, and high precision. The method was used for the pharmacokinetic evaluation of (+)-Borneol in Sprague-Dawley rats after intravenous, oral, and sublingual administration. The results indicate that oral bioavailability of (+)-Borneol was extremely low but sublingual administration yielded rapid absorption and favorable bioavailability of (+)-Borneol.
