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4beta,12-dihydroxyguaian-6,10-diene

CAS# 461644-90-6

4beta,12-dihydroxyguaian-6,10-diene

Catalog No. BCN7829----Order now to get a substantial discount!

Product Name & Size Price Stock
4beta,12-dihydroxyguaian-6,10-diene: 5mg $213 In Stock
4beta,12-dihydroxyguaian-6,10-diene: 10mg Please Inquire In Stock
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4beta,12-dihydroxyguaian-6,10-diene: 500mg Please Inquire Please Inquire
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Quality Control of 4beta,12-dihydroxyguaian-6,10-diene

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Chemical structure

4beta,12-dihydroxyguaian-6,10-diene

3D structure

Chemical Properties of 4beta,12-dihydroxyguaian-6,10-diene

Cas No. 461644-90-6 SDF Download SDF
PubChem ID 11139125 Appearance Powder
Formula C15H24O2 M.Wt 236.34
Type of Compound Monoterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (1S,3aR,8aS)-7-(2-hydroxypropan-2-yl)-1-methyl-4-methylidene-2,3,3a,5,6,8a-hexahydroazulen-1-ol
SMILES CC1(CCC2C1C=C(CCC2=C)C(C)(C)O)O
Standard InChIKey SYQJVLQILKBDAA-YDHLFZDLSA-N
Standard InChI InChI=1S/C15H24O2/c1-10-5-6-11(14(2,3)16)9-13-12(10)7-8-15(13,4)17/h9,12-13,16-17H,1,5-8H2,2-4H3/t12-,13-,15-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 4beta,12-dihydroxyguaian-6,10-diene

The rhizomes of Alisma orientale.

Biological Activity of 4beta,12-dihydroxyguaian-6,10-diene

Description4beta,12-dihydroxyguaian-6,10-diene is a natural product from Alisma orientale.
In vitro

A new triterpenoid from Alisma orientale and their antibacterial effect.[Pubmed: 23212633 ]

Arch Pharm Res. 2012 Nov;35(11):1919-26.

A new triterpenoid, named alisol Q 23-acetate, as well as fourteen known terpenes, alisol B 23-acetate (2), alisol B (3), alismol (4), 10-O-methyl-alismoxide (5), alismoxide (6), 11-deoxyalisol C (7), 13β,17β-epoxyalisol B 23-acetate (8), 4beta,12-dihydroxyguaian-6,10-diene (9), alisol C 23-acetate (10), alisolide (11), 16β-methoxyalisol B monoacetate (12), alisol A (13), 16β-hydroxyalisol B 23-acetate (14), alisol A 24-acetate (15) were isolated from the rhizomes of Alisma orientale.
METHODS AND RESULTS:
The structures of compounds (1-15) were identified based on 1D and 2D NMR, including (1)H-(1)H COSY, HSQC, HMBC and NOESY spectroscopic analyses. Among these isolates, antibacterial effect of compounds 2, 3, 10, and 15, major constituents of A. orientale was examined. The MIC values of compounds 2, 10, and 15 were 5-10 βg/mL against eight antibiotic resistant strains, which were lower than those from the positive controls (MICs of chloramphenicol and ampicillin were 5-80 μg/mL).
CONCLUSIONS:
Therefore, compounds 2, 10 and 15 exhibited the potent antibacterial activity.

4beta,12-dihydroxyguaian-6,10-diene Dilution Calculator

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4beta,12-dihydroxyguaian-6,10-diene Molarity Calculator

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Preparing Stock Solutions of 4beta,12-dihydroxyguaian-6,10-diene

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.2312 mL 21.156 mL 42.3119 mL 84.6238 mL 105.7798 mL
5 mM 0.8462 mL 4.2312 mL 8.4624 mL 16.9248 mL 21.156 mL
10 mM 0.4231 mL 2.1156 mL 4.2312 mL 8.4624 mL 10.578 mL
50 mM 0.0846 mL 0.4231 mL 0.8462 mL 1.6925 mL 2.1156 mL
100 mM 0.0423 mL 0.2116 mL 0.4231 mL 0.8462 mL 1.0578 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 4beta,12-dihydroxyguaian-6,10-diene

A new triterpenoid from Alisma orientale and their antibacterial effect.[Pubmed:23212633]

Arch Pharm Res. 2012 Nov;35(11):1919-26.

A new triterpenoid, named alisol Q 23-acetate, as well as fourteen known terpenes, alisol B 23-acetate (2), alisol B (3), alismol (4), 10-O-methyl-alismoxide (5), alismoxide (6), 11-deoxyalisol C (7), 13beta,17beta-epoxyalisol B 23-acetate (8), 4beta,12-dihydroxyguaian-6,10-diene (9), alisol C 23-acetate (10), alisolide (11), 16beta-methoxyalisol B monoacetate (12), alisol A (13), 16beta-hydroxyalisol B 23-acetate (14), alisol A 24-acetate (15) were isolated from the rhizomes of Alisma orientale. The structures of compounds (1-15) were identified based on 1D and 2D NMR, including (1)H-(1)H COSY, HSQC, HMBC and NOESY spectroscopic analyses. Among these isolates, antibacterial effect of compounds 2, 3, 10, and 15, major constituents of A. orientale was examined. The MIC values of compounds 2, 10, and 15 were 5-10 betag/mL against eight antibiotic resistant strains, which were lower than those from the positive controls (MICs of chloramphenicol and ampicillin were 5-80 mug/mL). Therefore, compounds 2, 10 and 15 exhibited the potent antibacterial activity.

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